CD72 Antibody - #DF7910

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Product: CD72 Antibody
Catalog: DF7910
Description: Rabbit polyclonal antibody to CD72
Application: WB IHC
Reactivity: Human, Mouse
Mol.Wt.: 40 kDa; 40kD(Calculated).
Uniprot: P21854
RRID: AB_2841327

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
CD72 Antibody detects endogenous levels of total CD72.
RRID:
AB_2841327
Cite Format: Affinity Biosciences Cat# DF7910, RRID:AB_2841327.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

B cell differentiation antigen CD72; B-cell differentiation antigen CD72; CD_antigen=CD72; CD72; CD72 antigen; CD72 molecule; CD72_HUMAN; CD72b; CD72c; Ly-19; Ly-32; Ly-m19; Lyb-2; Lyb2; LYB2, mouse, homolog of; Lymphocyte antigen 32; MGC108873;

Immunogens

Immunogen:
Uniprot:

P21854(CD72_HUMAN) >>Visit HPA database.

Gene(ID):
CD72(971)
Expression:
P21854 CD72_HUMAN:

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Sequence:
MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD

PTMs - P21854 As Substrate

Site PTM Type Enzyme
Y7 Phosphorylation P07948 (LYN)
Y39 Phosphorylation P07948 (LYN)
T110 Phosphorylation
S153 Phosphorylation
S167 Phosphorylation
K196 Methylation
T331 Phosphorylation
T353 Phosphorylation

Research Backgrounds

Function:

Plays a role in B-cell proliferation and differentiation.

PTMs:

Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).

Subcellular Location:

Membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Subunit Structure:

Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).

Research Fields

· Organismal Systems > Immune system > B cell receptor signaling pathway.   (View pathway)

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