PARVA Antibody - #DF7874

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Product: PARVA Antibody
Catalog: DF7874
Description: Rabbit polyclonal antibody to PARVA
Application: WB IHC IF/ICC
Reactivity: Human
Mol.Wt.: 42 kDa; 42kD(Calculated).
Uniprot: Q9NVD7
RRID: AB_2841302

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
PARVA Antibody detects endogenous levels of total PARVA.
RRID:
AB_2841302
Cite Format: Affinity Biosciences Cat# DF7874, RRID:AB_2841302.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Actopaxin; Alpha parvin; Alpha-parvin; Calponin like integrin linked kinase binding protein; Calponin-like integrin-linked kinase-binding protein; CH ILKBP; CH-ILKBP; FLJ10793; FLJ12254; Matrix remodelling associated 2; Matrix remodelling associated protein 2; Matrix-remodeling-associated protein 2; MXRA 2; MXRA2; PARV A; Parva; PARVA_HUMAN;

Immunogens

Immunogen:

A synthesized peptide derived from human PARVA, corresponding to a region within C-terminal amino acids.

Uniprot:

Q9NVD7(PARVA_HUMAN) >>Visit HPA database.

Gene(ID):
PARVA(55742)
Expression:
Q9NVD7 PARVA_HUMAN:

Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.

Sequence:
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE

PTMs - Q9NVD7 As Substrate

Site PTM Type Enzyme
T3 Phosphorylation
S4 Phosphorylation
S8 Phosphorylation
S10 Phosphorylation
S14 Phosphorylation
T16 Phosphorylation
S19 Phosphorylation
S22 Phosphorylation
S28 Phosphorylation
K32 Acetylation
K32 Ubiquitination
T36 Phosphorylation
S62 Phosphorylation
T82 Phosphorylation
K93 Ubiquitination
Y124 Phosphorylation
K131 Ubiquitination
K135 Ubiquitination
K140 Ubiquitination
K154 Ubiquitination
K156 Ubiquitination
T167 Phosphorylation
S174 Phosphorylation
T252 Phosphorylation
K260 Ubiquitination
T284 Phosphorylation
K343 Ubiquitination
Y362 Phosphorylation

Research Backgrounds

Function:

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.

Subcellular Location:

Cell junction>Focal adhesion. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cytoplasm>Myofibril>Sarcomere>Z line.
Note: Constituent of focal adhesions. Associates with the actin cytoskeleton.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.

Subunit Structure:

Interacts with TGFB1I1 (By similarity). Interacts with ILK, LIMS1 and PXN (via LD motifs). Interacts with ARHGAP31. Interacts with the actin cytoskeleton.

Family&Domains:

Belongs to the parvin family.

Research Fields

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

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