GLP1R Antibody - #DF7750

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Product: GLP1R Antibody
Catalog: DF7750
Description: Rabbit polyclonal antibody to GLP1R
Application: WB
Reactivity: Human, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 53 kDa;
Uniprot: p43220
RRID: AB_2841216

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
GLP1R Antibody detects endogenous levels of total GLP1R.
RRID:
AB_2841216
Cite Format: Affinity Biosciences Cat# DF7750, RRID:AB_2841216.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

GLP 1 R; GLP 1 receptor; GLP 1R; GLP; GLP-1 receptor; GLP-1-R; GLP-1R; GLP1R; GLP1R_HUMAN; Glucagon like peptide 1 receptor; Glucagon-like peptide 1 receptor; MGC138331; OTTHUMP00000016340;

Immunogens

Immunogen:
Gene(ID):
GLP1R(2740)

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

Research Fields

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

References

1). Geniposide ameliorates glucocorticoid-induced osteoblast apoptosis by activating autophagy. Biomedicine & Pharmacotherapy, 2022 (PubMed: 36271582) [IF=7.5]

Application: WB    Species: Rat    Sample: MC3T3-E1 cells

Fig. 8. GEN mediated autophagy by stimulating GLP-1R activity. The proteins expression of GLP-1R (A, B), PI3K (A, C), P-PI3K (A, D), AKT (A, E), P-AKT (A, F), mTOR (A, G), P-mTOR (A, H), P62 (A, I), LC3-II/I (A, J), Beclin-1 (A, K), and cleaved caspase3 (A, L) in DEX-treated MC3T3-E1 cells were determined by western blot. (M, N) The apoptosis was determined by a flow cytometer.
2). Effects of PPARD gene variants on the therapeutic responses to exenatide in chinese patients with type 2 diabetes mellitus. Frontiers in Endocrinology, 2022 (PubMed: 36051387) [IF=5.2]

Application: WB    Species: Human    Sample:

Figure 3 Effect of PPARδ agonists (GW501516) on the exenatide therapeutic efficacy by regulating the expression of GLP-1R. (A) Enzymatic methods were used to assay for glucose. (B) The mRNA level of GLP-1R was measured by RT-PCR. (C) The relative protein expression level of GLP-1R was measured by Western blot. Data are expressed as the mean ± SE, n = 3. * P < 0.05, ** P < 0.01 and *** P < 0.001 compared with IR. # P < 0.05, ## P < 0.01 and ### P < 0.001 compared with IR+Exendin-4.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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