BIGM103 Antibody - #DF7743
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7743, RRID:AB_2841210.
Fold/Unfold
4933419D20Rik; AA986696; BCG induced integral membrane protein 103; BCG induced integral membrane protein BIGMo-103 (Up-regulated by BCG-CWS) (Hypothetical protein); LIV-1 subfamily of ZIP zinc transporter 6; LZT Hs6; MGC108852; PP3105; SLC39A8; Solute carrier family 39 (zinc transporter), member 8 (SLC39A8); Solute carrier family 39 (zinc transporter), member 8; Solute carrier family 39 member 8; zinc transporter ZIP8; ZIP8; Zrt- and Irt-like protein 8;
Immunogens
Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.
- Q9C0K1 S39A8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9C0K1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S275 | Phosphorylation | Uniprot | |
| S278 | Phosphorylation | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| T424 | Phosphorylation | Uniprot |
Research Backgrounds
Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain.
Membrane>Multi-pass membrane protein.
Note: Associated with the lysosomal/endosomal compartment following transfection.
Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.
Belongs to the ZIP transporter (TC 2.A.5) family.
Research Fields
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
References
Application: IF/ICC Species: Human Sample: ESCC
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