GFRA4 Antibody - #AF0809

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Product: GFRA4 Antibody
Catalog: AF0809
Description: Rabbit polyclonal antibody to GFRA4
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 30kDa; 32kD(Calculated).
Uniprot: Q9GZZ7
RRID: AB_2834399

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
GFRA4 Antibody detects endogenous levels of total GFRA4.
RRID:
AB_2834399
Cite Format: Affinity Biosciences Cat# AF0809, RRID:AB_2834399.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

GDNF family receptor alpha 4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107; Persephin receptor;

Immunogens

Immunogen:
Uniprot:

Q9GZZ7(GFRA4_HUMAN) >>Visit HPA database.

Gene(ID):
GFRA4(64096)
Expression:
Q9GZZ7 GFRA4_HUMAN:

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

Description:
GFRA4 Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Belongs to the GDNFR family. 3 isoforms of the human protein are produced by alternative splicing.
Sequence:
MVRCLGPALLLLLLLGSASSVGGNRCVDAAEACTADARCQRLRSEYVAQCLGRAAQGGCPRARCRRALRRFFARGPPALTHALLFCPCAGPACAERRRQTFVPSCAFSGPGPAPPSCLEPLNFCERSRVCRCARAAAGPWRGWGRGLSPAHRPPAAQASPPGLSGLVHPSAQRPRRLPAGPGRPLPARLRGPRGVPAGTAVTPNYVDNVSARVAPWCDCGASGNRREDCEAFRGLFTRNRCLDGAIQAFASGWPPVLLDQLNPQGDPEHSLLQVSSTGRALERRSLLSILPVLALPALL

Research Backgrounds

Function:

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

Subcellular Location:

Cell membrane>Lipid-anchor.

Cell membrane>Lipid-anchor.

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

Subunit Structure:

Interacts with SORL1.

Family&Domains:

Belongs to the GDNFR family.

Restrictive clause

 

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For Research Use Only.
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