CSF2RB Antibody - #DF7680
| Product: | CSF2RB Antibody |
| Catalog: | DF7680 |
| Description: | Rabbit polyclonal antibody to CSF2RB |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 130 kDa; 97kD(Calculated). |
| Uniprot: | P32927 |
| RRID: | AB_2841151 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7680, RRID:AB_2841151.
Fold/Unfold
/granulocyte-macrophage colony-stimulating factor receptor, beta; Beta-C; CD131; CDw131; Colony stimulating factor 2 receptor beta; Colony stimulating factor 2 receptor beta low affinity (granulocyte macrophage); Common beta chain; Csf2rb; Cytokine receptor common beta chain; Cytokine receptor common beta chain precursor (CDw131 antigen); Cytokine receptor common subunit beta; GM CSF/IL 3/IL 5 receptor common beta chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; IL3RB; IL3RB_HUMAN; IL5RB; Interleukin 3 receptor, beta; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta (high affinity); Interleukin 5 receptor, beta; SMDP5; stimulating factor 3 receptor, beta (high affinity);
Immunogens
- P32927 IL3RB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVTLIRRVNEDLLEPVSCDLSDDMPWSACPHPRCVPRRCVIPCQSFVVTDVDYFSFQPDRPLGTRLTVTLTQHVQPPEPRDLQISTDQDHFLLTWSVALGSPQSHWLSPGDLEFEVVYKRLQDSWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAAVLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMAPPSLNVTKDGDSYSLRWETMKMRYEHIDHTFEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWDTESVLPMWVLALIVIFLTIAVLLALRFCGIYGYRLRRKWEEKIPNPSKSHLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGDSEVSPLTIEDPKHVCDPPSGPDTTPAASDLPTEQPPSPQPGPPAASHTPEKQASSFDFNGPYLGPPHSRSLPDILGQPEPPQEGGSQKSPPPGSLEYLCLPAGGQVQLVPLAQAMGPGQAVEVERRPSQGAAGSPSLESGGGPAPPALGPRVGGQDQKDSPVAIPMSSGDTEDPGVASGYVSSADLVFTPNSGASSVSLVPSLGLPSDQTPSLCPGLASGPPGAPGPVKSGFEGYVELPPIEGRSPRSPRNNPVPPEAKSPVLNPGERPADVSPTSPQPEGLLVLQQVGDYCFLPGLGPGPLSLRSKPSSPGPGPEIKNLDQAFQVKKPPGQAVPQVPVIQLFKALKQQDYLSLPPWEVNKPGEVC
PTMs - P32927 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N58 | N-Glycosylation | Uniprot | |
| N191 | N-Glycosylation | Uniprot | |
| S220 | Phosphorylation | Uniprot | |
| Y466 | Phosphorylation | P07948 (LYN) | Uniprot |
| Y468 | Phosphorylation | P07948 (LYN) | Uniprot |
| K473 | Ubiquitination | Uniprot | |
| K477 | Ubiquitination | Uniprot | |
| K483 | Ubiquitination | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S585 | Phosphorylation | P42336 (PIK3CA) | Uniprot |
| Y593 | Phosphorylation | Uniprot | |
| S601 | Phosphorylation | Uniprot | |
| Y628 | Phosphorylation | Uniprot | |
| Y711 | Phosphorylation | Uniprot | |
| Y766 | Phosphorylation | Uniprot | |
| Y822 | Phosphorylation | P07948 (LYN) | Uniprot |
| Y882 | Phosphorylation | P07948 (LYN) | Uniprot |
Research Backgrounds
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
May be phosphorylated by LYN.
Membrane>Single-pass type I membrane protein.
Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with FCER1G; this interaction is direct. Interacts with LYN.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Research Fields
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
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