VWA5A Antibody - #DF3007

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Product: VWA5A Antibody
Catalog: DF3007
Description: Rabbit polyclonal antibody to VWA5A
Application: WB IF/ICC
Reactivity: Human
Prediction: Horse, Dog
Mol.Wt.: 86 KD; 86kD(Calculated).
Uniprot: O00534
RRID: AB_2840986

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Horse(89%), Dog(80%)
Clonality:
Polyclonal
Specificity:
VWA5A Antibody detects endogenous levels of total VWA5A.
RRID:
AB_2840986
Cite Format: Affinity Biosciences Cat# DF3007, RRID:AB_2840986.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

BCSC 1;BCSC-1;BCSC1;Breast cancer suppressor candidate 1;LHR2A;LOH11CR2A;Loss of heterozygosity 11 chromosomal region 2 gene A;Loss of heterozygosity 11 chromosomal region 2 gene A protein;Ortholog of mouse AW551984;VMA5A_HUMAN;von Willebrand factor A domain containing 5A;von Willebrand factor A domain-containing protein 5A;Vwa5a;

Immunogens

Immunogen:
Uniprot:

O00534(VMA5A_HUMAN) >>Visit HPA database.

Gene(ID):
VWA5A(4013)
Expression:
O00534 VMA5A_HUMAN:

Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.

Sequence:
MVHFCGLLTLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLKYVQELPLEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTPIVPVEDLPYTLSMVATIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQVSLAAGHKFDRDVELLIYYNEVHTPSVVLEMGMPNMKPGHLMGDPSAMVSFYPNIPEDQPSNTCGEFIFLMDRSGSMQSPMSSQDTSQLRIQAAKETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLMQADLGGTEILAPLQNIYRGPSIPGHPLQLFVFTDGEVTDTFSVIKEVRINRQKHRCFSFGIGEGTSTSLIKGIARASGGTSEFITGKDRMQSKALRTLKRSLQPVVEDVSLSWHLPPGLSAKMLSPEQTVIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFEDKVTFPLQPKPDVNLTIHRLAAKSLLQTKDMGLRETPASDKKDALNLSLESGVISSFTAFIAINKELNKPVQGPLAHRDVPRPILLGASAPLKIKCQSGFRKALHSDRPPSASQPRGELMCYKAKTFQMDDYSLCGLISHKDQHSPGFGENHLVQLIYHQNANGSWDLNEDLAKILGMSLEEIMAAQPAELVDSSGWATILAVIWLHSNGKDLKCEWELLERKAVAWMRAHAGSTMPSVVKAAITFLKSSVDPAIFAF

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
89
Dog
80
Pig
73
Bovine
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O00534 As Substrate

Site PTM Type Enzyme
T9 Phosphorylation
K72 Ubiquitination
K80 Ubiquitination
K89 Ubiquitination
S92 Phosphorylation
S104 Phosphorylation
S106 Phosphorylation
K122 Ubiquitination
K128 Ubiquitination
K160 Ubiquitination
S162 Phosphorylation
S202 Phosphorylation
T204 Phosphorylation
S289 Phosphorylation
S291 Phosphorylation
K310 Ubiquitination
K358 Ubiquitination
S381 Phosphorylation
K447 Ubiquitination
S485 Phosphorylation
T489 Phosphorylation
K525 Ubiquitination
K597 Ubiquitination
S617 Phosphorylation
K621 Ubiquitination
K623 Ubiquitination
K630 Ubiquitination
S634 Phosphorylation
S639 Phosphorylation
K653 Ubiquitination
T654 Phosphorylation
Y660 Phosphorylation
S661 Phosphorylation
S673 Phosphorylation

Research Backgrounds

Function:

May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.

Tissue Specificity:

Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.

References

1). Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation. Apoptosis, 2021 (PubMed: 33550458) [IF=7.2]

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