CDC7 Antibody - #DF3005
| Product: | CDC7 Antibody |
| Catalog: | DF3005 |
| Description: | Rabbit polyclonal antibody to CDC7 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 70 KD; 64kD(Calculated). |
| Uniprot: | O00311 |
| RRID: | AB_2840984 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3005, RRID:AB_2840984.
Fold/Unfold
Cdc 7; CDC7; CDC7 cell division cycle 7; CDC7 cell division cycle 7 like 1; CDC7 L1; Cdc7 like 1; CDC7 related kinase; CDC7-related kinase; CDC7_HUMAN; CDC7L 1; CDC7L1; Cell division cycle 7 homolog; Cell division cycle 7 kinase; Cell division cycle 7 like protein 1; Cell division cycle 7 related protein kinase; Cell division cycle 7-related protein kinase; HsCDC 7; HsCdc7; Hsk 1; Hsk1; HuCDC 7; huCdc7; MGC117361; MGC126237; MGC126238;
Immunogens
- O00311 CDC7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O00311 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| K36 | Sumoylation | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| K59 | Sumoylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K179 | Sumoylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K235 | Sumoylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| K244 | Sumoylation | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K268 | Sumoylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K274 | Sumoylation | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| S297 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| K331 | Acetylation | Uniprot | |
| K331 | Sumoylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| T376 | Phosphorylation | P06493 (CDK1) , P24941 (CDK2) | Uniprot |
| T386 | Phosphorylation | Uniprot | |
| Y415 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| K451 | Acetylation | Uniprot | |
| K451 | Ubiquitination | Uniprot | |
| T472 | Phosphorylation | Uniprot | |
| K474 | Ubiquitination | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| K492 | Ubiquitination | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| S556 | Phosphorylation | Uniprot | |
| T559 | Phosphorylation | Uniprot | |
| K570 | Ubiquitination | Uniprot | |
| S573 | Phosphorylation | Uniprot |
PTMs - O00311 As Enzyme
| Substrate | Site | Source |
|---|---|---|
| O75475 (PSIP1) | S206 | Uniprot |
| P49736 (MCM2) | S4 | Uniprot |
| P49736 (MCM2) | S5 | Uniprot |
| P49736 (MCM2) | S7 | Uniprot |
| P49736 (MCM2) | S13 | Uniprot |
| P49736 (MCM2) | S27 | Uniprot |
| P49736 (MCM2) | S31 | Uniprot |
| P49736 (MCM2) | S40 | Uniprot |
| P49736 (MCM2) | S41 | Uniprot |
| P49736 (MCM2) | S53 | Uniprot |
| P49736 (MCM2) | S108 | Uniprot |
| P49736 (MCM2) | S139 | Uniprot |
| P49736 (MCM2) | S220 | Uniprot |
| Q9HAW4 (CLSPN) | S67 | Uniprot |
| Q9HAW4 (CLSPN) | S110 | Uniprot |
| Q9HAW4 (CLSPN) | S260 | Uniprot |
| Q9HAW4 (CLSPN) | S265 | Uniprot |
| Q9HAW4 (CLSPN) | S704 | Uniprot |
| Q9HAW4 (CLSPN) | S721 | Uniprot |
| Q9HAW4 (CLSPN) | S744 | Uniprot |
| Q9HAW4 (CLSPN) | S1129 | Uniprot |
| Q9HAW4 (CLSPN) | S1147 | Uniprot |
| Q9NS91 (RAD18) | S434 | Uniprot |
Research Backgrounds
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
Nucleus.
Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
Research Fields
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
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