LRP1/CD91 Antibody - #DF2935
(4)
(29)
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2935, RRID:AB_2840921.
Fold/Unfold
A2MR; Alpha 2 macroglobulin receptor; alpha 2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; APR; CD 91; CD91; CD91 antigen; IGFBP3R; LDL receptor related protein 1; Low density lipoprotein receptor related protein 1; Low density lipoprotein related protein 1; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRP 1; LRP 515; LRP 85; LRP; LRP ICD; LRP-1; LRP-515; LRP-85; Lrp1; LRP1 protein; LRP1_HUMAN; LRP1A; LRP515; LRP85; LRPICD; MGC88725; Prolow density lipoprotein receptor related protein 1; TbetaR V/LRP 1/IGFBP 3 receptor; TbetaRV/LRP1/IGFBP3 receptor; TGFBR 5; TGFBR5; Type V tgf beta receptor;
Immunogens
- Q07954 LRP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q07954 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K336 | Ubiquitination | Uniprot | |
| N446 | N-Glycosylation | Uniprot | |
| K458 | Methylation | Uniprot | |
| S511 | Phosphorylation | Uniprot | |
| Y530 | Phosphorylation | Uniprot | |
| R539 | Methylation | Uniprot | |
| T648 | Phosphorylation | Uniprot | |
| N729 | N-Glycosylation | Uniprot | |
| T894 | O-Glycosylation | Uniprot | |
| S897 | O-Glycosylation | Uniprot | |
| T1101 | O-Glycosylation | Uniprot | |
| S1417 | Phosphorylation | Uniprot | |
| S1419 | Phosphorylation | Uniprot | |
| T1430 | Phosphorylation | Uniprot | |
| S1432 | Phosphorylation | Uniprot | |
| T1440 | Phosphorylation | Uniprot | |
| Y1443 | Phosphorylation | Uniprot | |
| T1498 | Phosphorylation | Uniprot | |
| T1500 | Phosphorylation | Uniprot | |
| N1511 | N-Glycosylation | Uniprot | |
| T1513 | Phosphorylation | Uniprot | |
| N1575 | N-Glycosylation | Uniprot | |
| Y1587 | Phosphorylation | Uniprot | |
| N1616 | N-Glycosylation | Uniprot | |
| N1645 | N-Glycosylation | Uniprot | |
| S1754 | Phosphorylation | Uniprot | |
| N1763 | N-Glycosylation | Uniprot | |
| K1788 | Acetylation | Uniprot | |
| T1790 | Phosphorylation | Uniprot | |
| N2127 | N-Glycosylation | Uniprot | |
| T2156 | Phosphorylation | Uniprot | |
| Y2290 | Phosphorylation | Uniprot | |
| S2559 | Phosphorylation | Uniprot | |
| Y2560 | Phosphorylation | Uniprot | |
| S2563 | Phosphorylation | Uniprot | |
| R2577 | Methylation | Uniprot | |
| S2621 | Phosphorylation | Uniprot | |
| T2773 | O-Glycosylation | Uniprot | |
| N2815 | N-Glycosylation | Uniprot | |
| T2857 | O-Glycosylation | Uniprot | |
| N3048 | N-Glycosylation | Uniprot | |
| N3089 | N-Glycosylation | Uniprot | |
| S3142 | Phosphorylation | Uniprot | |
| T3261 | Phosphorylation | Uniprot | |
| N3488 | N-Glycosylation | Uniprot | |
| R3500 | Methylation | Uniprot | |
| T3535 | O-Glycosylation | Uniprot | |
| T3735 | O-Glycosylation | Uniprot | |
| N3788 | N-Glycosylation | Uniprot | |
| S3928 | Phosphorylation | Uniprot | |
| N3953 | N-Glycosylation | Uniprot | |
| K3988 | Acetylation | Uniprot | |
| S4067 | Phosphorylation | Uniprot | |
| S4071 | Phosphorylation | Uniprot | |
| N4075 | N-Glycosylation | Uniprot | |
| N4125 | N-Glycosylation | Uniprot | |
| S4249 | Phosphorylation | Uniprot | |
| K4452 | Ubiquitination | Uniprot | |
| T4460 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| Y4473 | Phosphorylation | P12931 (SRC) | Uniprot |
| Y4507 | Phosphorylation | P12931 (SRC) | Uniprot |
| Y4511 | Phosphorylation | Uniprot | |
| S4517 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S4520 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| S4523 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K4527 | Ubiquitination | Uniprot |
Research Backgrounds
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts as an alpha-2-macroglobulin receptor.
(Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
The N-terminus is blocked.
Phosphorylated on serine and threonine residues.
Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Cell membrane>Single-pass type I membrane protein. Membrane>Coated pit.
Cell membrane>Peripheral membrane protein>Extracellular side. Membrane>Coated pit.
Cytoplasm. Nucleus.
Note: After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Postsynaptic Golgi apparatus. Cytoplasm>Cytoskeleton>Microtubule organizing center.
Note: Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.
Most abundant in liver, brain and lung.
Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Can weakly interact (via NPXY motif) with DAB2 (via PID domain); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif. Interacts with bacterial exotoxins. Interacts with MDK; promotes neuronal survival. Interacts with uPA/PLAU and PAI1/SERPINE1, either individually or in complex with each other, leading to rapid endocytosis; this interaction is abolished in the presence of LRPAP1/RAP. Also interacts with tPA/PLAT alone or in complex with SERPINE1. Interacts with the urokinase receptor PLAUR; this interaction leads to PLAUR internalization and is impaired in the presence of SORL1. Interacts with LRPAP1; this interaction is followed by rapid internalization. Interacts with PDGFB.
Belongs to the LDLR family.
Research Fields
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Infectious diseases: Parasitic > Malaria.
· Organismal Systems > Digestive system > Cholesterol metabolism.
References
Application: IF/ICC Species: human Sample: Caco-2 cells
Application: WB Species: Mouse Sample:
Application: WB Species: human Sample: GC cells
Application: WB Species: rat Sample: hippocampus
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