KIFC1 Antibody - #DF2934

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Product: KIFC1 Antibody
Catalog: DF2934
Description: Rabbit polyclonal antibody to KIFC1
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 74kDa; 74kD(Calculated).
Uniprot: Q9BW19
RRID: AB_2840920

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(86%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(86%), Dog(100%)
Clonality:
Polyclonal
Specificity:
KIFC1 Antibody detects endogenous levels of total KIFC1.
RRID:
AB_2840920
Cite Format: Affinity Biosciences Cat# DF2934, RRID:AB_2840920.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HSET; HSET KNSL2; KIF C1; KIFC 1; KIFC1; KIFC1_HUMAN; Kinesin family member C1; Kinesin like 2; Kinesin like protein 2; Kinesin like protein KIFC1; Kinesin related protein HSET; Kinesin-like protein 2; Kinesin-like protein KIFC1; Kinesin-related protein HSET; KNSL 2; KNSL2; MGC1202; MGC149736; MGC149737; Mitotic kinesin like protein 2; MKLP 2; MKLP2; RAB6 KIFL; Rabkinesin 6;

Immunogens

Immunogen:
Uniprot:

Q9BW19(KIFC1_HUMAN) >>Visit HPA database.

Gene(ID):
KIFC1(3833)
Sequence:
MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATTKITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTSGVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKALGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEERRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRLHNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANRK

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Pig
86
Rabbit
86
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9BW19 As Substrate

Site PTM Type Enzyme
S6 Phosphorylation
K23 Methylation
K23 Ubiquitination
S26 Phosphorylation O14757 (CHEK1)
S31 Phosphorylation
S33 Phosphorylation
R54 Methylation
K61 Acetylation
S71 Phosphorylation
T82 Phosphorylation
S96 Phosphorylation
K107 Acetylation
K107 Ubiquitination
K140 Ubiquitination
K151 Ubiquitination
K179 Ubiquitination
K194 Ubiquitination
K207 Ubiquitination
K232 Ubiquitination
K251 Ubiquitination
S271 Phosphorylation
K308 Ubiquitination
S351 Phosphorylation
T359 Phosphorylation
S361 Phosphorylation
S373 Phosphorylation
K479 Ubiquitination
R489 Methylation
S494 Phosphorylation
K511 Ubiquitination
K609 Ubiquitination
K619 Ubiquitination
Y622 Phosphorylation
K659 Ubiquitination

Research Backgrounds

Function:

Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

Subcellular Location:

Nucleus. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Spindle. Early endosome.
Note: Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).

Family&Domains:

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.

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