TAS2R46 Antibody - #DF10303

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Product: TAS2R46 Antibody
Catalog: DF10303
Description: Rabbit polyclonal antibody to TAS2R46
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 36 kDa; 36kD(Calculated).
Uniprot: P59540
RRID: AB_2840881

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
TAS2R46 Antibody detects endogenous levels of total TAS2R46.
RRID:
AB_2840881
Cite Format: Affinity Biosciences Cat# DF10303, RRID:AB_2840881.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Immunogens

Immunogen:
Uniprot:

P59540(T2R46_HUMAN) >>Visit HPA database.

Gene(ID):
TAS2R46(259292)
Expression:
P59540 T2R46_HUMAN:

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.

Sequence:
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS

PTMs - P59540 As Substrate

Site PTM Type Enzyme
T191 Phosphorylation
T289 Phosphorylation

Research Backgrounds

Function:

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).

Subcellular Location:

Membrane>Multi-pass membrane protein. Cell projection>Cilium membrane.
Note: In airway epithelial cells, localizes to motile cilia.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.

Family&Domains:

Belongs to the G-protein coupled receptor T2R family.

Research Fields

· Organismal Systems > Sensory system > Taste transduction.

Restrictive clause

 

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For Research Use Only.
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