Product: LT4R1 Antibody
Catalog: DF10223
Description: Rabbit polyclonal antibody to LT4R1
Application: WB IHC
Reactivity: Human, Mouse, Rat, Monkey
Prediction: Horse, Rabbit, Dog
Mol.Wt.: 38 kDa; 38kD(Calculated).
Uniprot: Q15722
RRID: AB_2840801

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat,Monkey
Prediction:
Horse(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
LT4R1 Antibody detects endogenous levels of total LT4R1.
RRID:
AB_2840801
Cite Format: Affinity Biosciences Cat# DF10223, RRID:AB_2840801.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

BLT; BLT1; BLTR; Chemoattractant receptor-like 1; Chemokine receptor like 1; CMKRL1; G protein coupled receptor 16; G-protein coupled receptor 16; GPR16; Leukotriene B4 G Protein coupled receptor; Leukotriene B4 receptor 1; Leukotriene B4 receptor; LT4R1_HUMAN; LTB4 R 1; LTB4-R 1; LTB4-R1; LTB4R 1; Ltb4r; LTB4R1; LTBR1; P2RY7; P2Y purinoceptor 7; P2Y7; Purinergic receptor P2Y G protein coupled 7;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q15722 LT4R1_HUMAN:

Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

Sequence:
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Dog
100
Rabbit
100
Pig
0
Bovine
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q15722 As Substrate

Site PTM Type Enzyme
S104 Phosphorylation
T150 Phosphorylation
T308 Phosphorylation P43250 (GRK6)
S310 Phosphorylation
S313 Phosphorylation
S314 Phosphorylation
T315 Phosphorylation
S320 Phosphorylation

Research Backgrounds

Function:

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

PTMs:

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

Family&Domains:

Belongs to the G-protein coupled receptor 1 family.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

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