KRT81/86 Antibody - #DF10117
| Product: | KRT81/86 Antibody |
| Catalog: | DF10117 |
| Description: | Rabbit polyclonal antibody to KRT81/86 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 54 kDa; 54kD,55kD(Calculated). |
| Uniprot: | O43790 | Q14533 |
| RRID: | AB_2840697 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF10117, RRID:AB_2840697.
Fold/Unfold
Hair keratin K2.11; Hb6; K86; Keratin; Keratin-86; KRT86; KRT86_HUMAN; KRTHB6; MNX; type II cuticular Hb6; Type II hair keratin Hb6; Type-II keratin Kb26; 1; basic; ghHb 1; ghHb1; ghHkb 1; ghHKb1; hair; Hair keratin K2.9; Hard keratin type II 1; HB 1; HB1; hHAKB2 1; K2.9; K81; Keratin 81; Keratin; Keratin hair basic 1; Keratin type II cuticular Hb1; Keratin-81; Keratin81; KRT 81; KRT81; KRT81_HUMAN; KRTHB 1; KRTHB1; Metastatic lymph node 137 gene protein; MLN 137; MLN137; type II cuticular Hb1; Type II hair keratin Hb1; Type-II keratin Kb21;
Immunogens
Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.
Q14533 KRT81_HUMAN:Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue.
- O43790 KRT86_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTCGSYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVSSVPSNSNVVVGTTNACAPSARVGVCGGSCKRC
- Q14533 KRT81_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC
PTMs - O43790/Q14533 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S47 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K193 | Methylation | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| K222 | Methylation | Uniprot | |
| Y243 | Phosphorylation | Uniprot | |
| Y282 | Phosphorylation | Uniprot | |
| Y297 | Phosphorylation | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| T307 | Phosphorylation | Uniprot | |
| T314 | Phosphorylation | Uniprot | |
| T318 | Phosphorylation | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| K377 | Methylation | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| T466 | Phosphorylation | Uniprot | |
| S482 | Phosphorylation | Uniprot |
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S47 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| Y282 | Phosphorylation | Uniprot | |
| Y297 | Phosphorylation | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| T307 | Phosphorylation | Uniprot | |
| T314 | Phosphorylation | Uniprot | |
| T318 | Phosphorylation | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| S395 | Phosphorylation | Uniprot |
Research Backgrounds
Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.
Heterotetramer of two type I and two type II keratins.
Belongs to the intermediate filament family.
Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue.
Heterotetramer of two type I and two type II keratins.
Belongs to the intermediate filament family.
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