YAF2 Antibody - #DF10063
| Product: | YAF2 Antibody |
| Catalog: | DF10063 |
| Description: | Rabbit polyclonal antibody to YAF2 |
| Application: | WB |
| Reactivity: | Human |
| Prediction: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 20 kDa; 20kD(Calculated). |
| Uniprot: | Q8IY57 |
| RRID: | AB_2840643 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF10063, RRID:AB_2840643.
Fold/Unfold
MGC41856; YAF2; YAF2_HUMAN; YY1-associated factor 2;
Immunogens
- Q8IY57 YAF2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKTKSPPASSAASADQHSQSGSSSDNTERGMSRSSSPRGEASSLNGESH
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IY57 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| T65 | Phosphorylation | Uniprot | |
| K94 | Methylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K99 | Methylation | Uniprot | |
| T134 | Phosphorylation | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| S174 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot |
Research Backgrounds
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
Nucleus.
Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.
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For Research Use Only.
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