MUC13 Antibody - #AF0465

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Product: MUC13 Antibody
Catalog: AF0465
Description: Rabbit polyclonal antibody to MUC13
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 50kDa; 55kD(Calculated).
Uniprot: Q9H3R2
RRID: AB_2834337

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
MUC13 Antibody detects endogenous levels of total MUC13.
RRID:
AB_2834337
Cite Format: Affinity Biosciences Cat# AF0465, RRID:AB_2834337.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Down-regulated in colon cancer 1; DRCC1; FLJ20063; MUC 13; MUC-13; Muc13; MUC13 Down regulated in colon cancer 1; MUC13_HUMAN; Mucin 13, cell surface associated; Mucin-13; PRO20221; RECC; UNQ6194;

Immunogens

Immunogen:
Uniprot:

Q9H3R2(MUC13_HUMAN) >>Visit HPA database.

Gene(ID):
MUC13(56667)
Expression:
Q9H3R2 MUC13_HUMAN:

Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

Description:
MUC13 Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. Homodimer of beta subunits.
Sequence:
MKAIIHLTLLALLSVNTATNQGNSADAVTTTETATSGPTVAAADTTETNFPETASTTANTPSFPTATSPAPPIISTHSSSTIPTPAPPIISTHSSSTIPIPTAADSESTTNVNSLATSDIITASSPNDGLITMVPSETQSNNEMSPTTEDNQSSGPPTGTALLETSTLNSTGPSNPCQDDPCADNSLCVKLHNTSFCLCLEGYYYNSSTCKKGKVFPGKISVTVSETFDPEEKHSMAYQDLHSEITSLFKDVFGTSVYGQTVILTVSTSLSPRSEMRADDKFVNVTIVTILAETTSDNEKTVTEKINKAIRSSSSNFLNYDLTLRCDYYGCNQTADDCLNGLACDCKSDLQRPNPQSPFCVASSLKCPDACNAQHKQCLIKKSGGAPECACVPGYQEDANGNCQKCAFGYSGLDCKDKFQLILTIVGTIAGIVILSMIIALIVTARSNNKTKHIEEENLIDEDFQNLKLRSTGFTNLGAEGSVFPKVRITASRDSQMQNPYSRHSSMPRPDY

PTMs - Q9H3R2 As Substrate

Site PTM Type Enzyme
K308 Ubiquitination
K468 Ubiquitination
S471 Phosphorylation
S482 Phosphorylation
S495 Phosphorylation
Y501 Phosphorylation
S502 Phosphorylation
S506 Phosphorylation
Y512 Phosphorylation

Research Backgrounds

Function:

Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

PTMs:

Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds.

Highly N-glycosylated.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein. Apical cell membrane. Secreted.
Note: Also exists as a soluble form.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

Subunit Structure:

Homodimer of beta subunits.

Restrictive clause

 

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