Phospho-STYK1/NOK (Tyr327) Antibody - #AF8513
| Product: | Phospho-STYK1/NOK (Tyr327) Antibody |
| Catalog: | AF8513 |
| Description: | Rabbit polyclonal antibody to Phospho-STYK1/NOK (Tyr327) |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 47kDa; 48kD(Calculated). |
| Uniprot: | Q6J9G0 |
| RRID: | AB_2840567 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF8513, RRID:AB_2840567.
Fold/Unfold
DKFZp761P1010; NOK; Novel oncogene with kinase domain; Protein kinase STYK1; Protein PK unique; Protein PK-unique; Serine/threonine/tyrosine kinase 1; Styk 1; STYK1; STYK1_HUMAN; SuRTK 106; SuRTK106; Tyrosine protein kinase STYK1; Tyrosine-protein kinase STYK1;
Immunogens
Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.
- Q6J9G0 STYK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYSML
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6J9G0 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S59 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| T90 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| Y221 | Phosphorylation | Uniprot | |
| T224 | Phosphorylation | Uniprot |
Research Backgrounds
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
Membrane>Single-pass membrane protein.
Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.
Belongs to the protein kinase superfamily. Tyr protein kinase family.
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