ECRG4 Antibody - #AF0475

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Product: ECRG4 Antibody
Catalog: AF0475
Description: Rabbit polyclonal antibody to ECRG4
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 17kDa; 17kD(Calculated).
Uniprot: Q9H1Z8
RRID: AB_2834335

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, IF/ICC 1:100-1:500, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
ECRG4 Antibody detects endogenous levels of total ECRG4.
RRID:
AB_2834335
Cite Format: Affinity Biosciences Cat# AF0475, RRID:AB_2834335.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

AUGN_HUMAN; Augurin; C2orf40; Esophageal cancer-related gene 4 protein;

Immunogens

Immunogen:

A synthesized peptide derived from human ECRG4, corresponding to a region within C-terminal amino acids.

Uniprot:

Q9H1Z8(AUGN_HUMAN) >>Visit HPA database.

Gene(ID):
C2orf40(84417)
Expression:
Q9H1Z8 AUGN_HUMAN:

Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level).

Description:
C2orf40 Probable hormone. Belongs to the augurin family.
Sequence:
MAASPARPAVLALTGLALLLLLCWGPGGISGNKLKLMLQKREAPVPTKTKVAVDENKAKEFLGSLKRQKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDITYWLNRDRNGHEYYGDYYQRHYDEDSAIGPRSPYGFRHGASVNYDDY

PTMs - Q9H1Z8 As Substrate

Site PTM Type Enzyme
K48 Methylation
K50 Methylation
K57 Methylation

Research Backgrounds

Function:

Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity).

Subcellular Location:

Secreted. Cytoplasm. Apical cell membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level).

Family&Domains:

Belongs to the augurin family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

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