ATPBD3 Antibody - #AF0721
| Product: | ATPBD3 Antibody |
| Catalog: | AF0721 |
| Description: | Rabbit polyclonal antibody to ATPBD3 |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine |
| Mol.Wt.: | 36~43kDa; 36kD(Calculated). |
| Uniprot: | Q7Z7A3 |
| RRID: | AB_2834295 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0721, RRID:AB_2834295.
Fold/Unfold
ATP binding domain 3; ATP-binding domain-containing protein 3; Cancer associated protein; Cancer-associated gene protein; ctu1; CTU1_HUMAN; Cytoplasmic tRNA 2-thiolation protein 1; Cytoplasmic tRNA adenylyltransferase 1; Cytosolic thiouridylase subunit 1 homolog; NCS6;
Immunogens
- Q7Z7A3 CTU1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPAPPCASCHAARAALRRPLSGQALCGACFCAAFEAEVLHTVLAGRLLPPGAVVAVGASGGKDSTVLAHVLRALAPRLGISLQLVAVDEGIGGYRDAALAAVRRQAARWELPLTVVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGARRVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGGLGSPGEGGALPRCRPLQFASQKEVVLYAHFRRLDYFSEECVYAPEAFRGHARDLLKRLEAARPSAVLDLVHSAERLALAPAARPPRPGACSRCGALASRALCQACALLDGLNRGRPRLAIGKGRRGLDEEATPGTPGDPARPPASKAVPTF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q7Z7A3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S81 | Phosphorylation | Uniprot | |
| Y94 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| T145 | Phosphorylation | Uniprot | |
| R194 | Methylation | Uniprot | |
| S200 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| T329 | Phosphorylation | Uniprot | |
| T332 | Phosphorylation | Uniprot | |
| K343 | Ubiquitination | Uniprot |
Research Backgrounds
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Cytoplasm.
Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
Research Fields
· Genetic Information Processing > Folding, sorting and degradation > Sulfur relay system. (View pathway)
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