Product: OGR1/GPR68 Antibody
Catalog: AF0723
Description: Rabbit polyclonal antibody to OGR1/GPR68
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 40~70 kD; 41kD(Calculated).
Uniprot: Q15743
RRID: AB_2834264

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
OGR1/GPR68 Antibody detects endogenous levels of total OGR1/GPR68.
RRID:
AB_2834264
Cite Format: Affinity Biosciences Cat# AF0723, RRID:AB_2834264.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

G protein coupled receptor 68; G-protein coupled receptor 68; GPR 12A; GPR 68; GPR12A; Gpr68; MGC111379; MGC156983; OGR 1; OGR-1; OGR1; OGR1_HUMAN; Ovarian cancer G protein coupled receptor 1; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q15743 OGR1_HUMAN:

Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.

Description:
Protein type: Secreted; Secreted, signal peptide Cellular Component: extracellular region
Sequence:
MGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFRFHQFRTLKAAVGVSVVIWAKELLTSIYFLMHEEVIEDENQHRVCFEHYPIQAWQRAINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASCDFAKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQTPNSPGSGGFPTGRLA

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
73
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q15743 As Substrate

Site PTM Type Enzyme
Y187 Phosphorylation
Y188 Phosphorylation
Y244 Phosphorylation
S328 Phosphorylation
S331 Phosphorylation
S353 Phosphorylation

Research Backgrounds

Function:

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.

Family&Domains:

Belongs to the G-protein coupled receptor 1 family.

Restrictive clause

 

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For Research Use Only.
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