G3BP2 Antibody - #DF4387
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Product: | G3BP2 Antibody |
Catalog: | DF4387 |
Description: | Rabbit polyclonal antibody to G3BP2 |
Application: | WB IHC IF/ICC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
Mol.Wt.: | 55 KD; 54kD(Calculated). |
Uniprot: | Q9UN86 |
RRID: | AB_2836742 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4387, RRID:AB_2836742.
Fold/Unfold
G3BP 2; G3BP-2; G3BP2; G3BP2_HUMAN; GAP SH3 domain binding protein 2; GAP SH3 domain-binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; Ras GTPase activating protein SH3 domain binding protein 2; Ras GTPase-activating protein-binding protein 2;
Immunogens
- Q9UN86 G3BP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQNDIHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFGDSEPELDEESEDEVEEEQEERQPSPEPVQENANSGYYEAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKNLEELEEKSTTPPPAEPVSLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQPRVEAKPEVQSQPPRVREQRPRERPGFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEEKKTRAARERETRGGGDDRRDIRRNDRGPGGPRGIVGGGMMRDRDGRGPPPRGGMAQKLGSGRGTGQMEGRFTGQRR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UN86 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K5 | Ubiquitination | Uniprot | |
S7 | Phosphorylation | Uniprot | |
K25 | Ubiquitination | Uniprot | |
R32 | Methylation | Uniprot | |
S48 | Phosphorylation | Uniprot | |
K50 | Ubiquitination | Uniprot | |
Y56 | Phosphorylation | Uniprot | |
K64 | Ubiquitination | Uniprot | |
S67 | Phosphorylation | Uniprot | |
K76 | Acetylation | Uniprot | |
K76 | Ubiquitination | Uniprot | |
K107 | Ubiquitination | Uniprot | |
T111 | Phosphorylation | Uniprot | |
K123 | Ubiquitination | Uniprot | |
S141 | Phosphorylation | Uniprot | |
S149 | Phosphorylation | Uniprot | |
S163 | Phosphorylation | Uniprot | |
Y175 | Phosphorylation | Uniprot | |
Y176 | Phosphorylation | Uniprot | |
T206 | Phosphorylation | Uniprot | |
S225 | Phosphorylation | Uniprot | |
T226 | Phosphorylation | Uniprot | |
T227 | Phosphorylation | Uniprot | |
S235 | Phosphorylation | Uniprot | |
K281 | Sumoylation | Uniprot | |
S353 | Phosphorylation | Uniprot | |
T364 | Phosphorylation | Uniprot | |
K370 | Acetylation | Uniprot | |
K370 | Ubiquitination | Uniprot | |
K392 | Ubiquitination | Uniprot | |
R432 | Methylation | Uniprot | |
R438 | Methylation | Uniprot | |
R447 | Methylation | Uniprot | |
R452 | Methylation | Uniprot | |
R457 | Methylation | Uniprot | |
S466 | Phosphorylation | Uniprot | |
R468 | Methylation | Uniprot | |
R476 | Methylation | Uniprot |
Research Backgrounds
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.
Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
(Microbial infection) Cleaved by foot-and-mouth disease virus leader protease; this cleavage suppresses the formation of cytoplasmic stress granules.
Cytoplasm. Cytoplasm>Stress granule.
Forms homooligomers. Forms heterodimers with G3BP1. Interacts with NFKBIA (via N-terminus). Interacts with USP10. Interacts with PABPC1.
(Microbial infection) Interacts with Sindbis virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-G3BP2 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes.
References
Application: WB Species: Mouse Sample:
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