AFfirm™ CHCHD6 Mouse Monoclonal Antibody - #BF8894
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
CHCH6_HUMAN; Chchd6; CHCM1; Coiled coil helix cristae morphology 1; Coiled coil helix cristae morphology protein 1; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; Mic25; MICOS complex subunit MIC25; PPP1R23; Protein phosphatase 1 regulatory subunit 23;
Immunogens
- Q9BRQ6 MIC25_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG
PTMs - Q9BRQ6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S13 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| T49 | Phosphorylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| K84 | Acetylation | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K106 | Acetylation | Uniprot | |
| K114 | Acetylation | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| K117 | Acetylation | Uniprot | |
| K133 | Acetylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| T153 | Phosphorylation | Uniprot | |
| Y155 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| Y170 | Phosphorylation | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| S186 | Phosphorylation | Uniprot | |
| T187 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Mitochondrion inner membrane>Lipid-anchor. Mitochondrion.
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with DISC1. Interacts with DISC1. Interacts with IMMT/MIC60.
Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
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