AFfirm™ Centaurin alpha 1 Mouse Monoclonal Antibody - #BF8889

Product: Centaurin alpha 1 Mouse Monoclonal Antibody
Catalog: BF8889
Description: Mouse monoclonal antibody to Centaurin alpha 1
Application: WB
Reactivity: Human
Prediction: Mouse, Rat
Mol.Wt.: 40-50kD; 43kD(Calculated).
Uniprot: O75689

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8889]
Specificity:
Centaurin alpha 1 Mouse Monoclonal Antibody detects endogenous levels of total Centaurin alpha 1.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ArfGAP with dual PH domains 1; CENTA 1; CENTA1; Centaurin alpha; GCS1L; p42IP4; Putative MAPK activating protein PM25;

Immunogens

Immunogen:

A synthesized peptide derived from Human Centaurin alpha 1.

Uniprot:

O75689(ADAP1_HUMAN) >>Visit HPA database.

Gene(ID):
ADAP1(11033)
Expression:
O75689 ADAP1_HUMAN:

Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.

Sequence:
MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP

Research Backgrounds

Function:

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

PTMs:

Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro.

Subcellular Location:

Nucleus. Cytoplasm.
Note: Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.

Subunit Structure:

Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

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