AFfirm™ TMOD1 Mouse Monoclonal Antibody - #BF8843
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
D9S57E; E Tmod; E tropomodulin; E-Tmod; Erythrocyte tropomodulin; ETMOD; MGC124125; MGC124126; OTTHUMP00000021743; TMOD; Tmod1; TMOD1 protein; TMOD1_HUMAN; Tropomodulin 1; Tropomodulin-1;
Immunogens
- P28289 TMOD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV
PTMs - P28289 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Q96QT4 (TRPM7) | Uniprot |
| Y3 | Phosphorylation | Uniprot | |
| Y10 | Phosphorylation | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| T54 | Phosphorylation | Q96QT4 (TRPM7) | Uniprot |
| Y87 | Phosphorylation | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| Y242 | Phosphorylation | Uniprot | |
| Y278 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot |
Research Backgrounds
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
Cytoplasm>Cytoskeleton.
Note: In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).
Highly expressed in the erythrocyte, heart and skeletal muscle.
Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin.
Belongs to the tropomodulin family.
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