AFfirm™ KIRREL2 Mouse Monoclonal Antibody - #BF8810

Product: KIRREL2 Mouse Monoclonal Antibody
Catalog: BF8810
Description: Mouse monoclonal antibody to KIRREL2
Application: WB
Reactivity: Human
Prediction: Mouse
Mol.Wt.: 75kD(Calculated).
Uniprot: Q6UWL6

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8810]
Specificity:
KIRREL2 Mouse Monoclonal Antibody detects endogenous levels of KIRREL2.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FILTRIN; Kin of IRRE like 2 (Drosophila); Kin of IRRE-like protein 2; Kin of irregular chiasm like 2; Kin of irregular chiasm-like protein 2; KIRR2_HUMAN; KIRREL2; NEPH3; Nephrin like 3; nephrin-like gene 1; Nephrin-like protein 3; NLG1;

Immunogens

Immunogen:

A synthesized peptide derived from human KIRREL2.

Uniprot:

Q6UWL6(KIRR2_HUMAN) >>Visit HPA database.

Gene(ID):
KIRREL2(84063)
Expression:
Q6UWL6 KIRR2_HUMAN:

Highly expressed in beta-cells of the pancreatic islets.

Sequence:
MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPTNGYYKVRGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPTFYDFNPHLGMVPPCRLYRARAGYLTTPHPRAFTSYIKPTSFGPPDLAPGTPPFPYAAFPTPSHPRLQTHV

Research Backgrounds

Function:

May regulate basal insulin secretion.

PTMs:

N-glycosylated.

The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein.
Note: Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in beta-cells of the pancreatic islets.

Subunit Structure:

Homodimer. Interacts with NPHS2/podocin (via the C-terminus). Interacts with NPHS1 (via the Ig-like domains). Interacts with FYN.

Family&Domains:

Belongs to the immunoglobulin superfamily.

Restrictive clause

 

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