AFfirm™ FAF2 Mouse Monoclonal Antibody - #BF8789
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
AI462440; expressed in T cells and eosinophils in atopic dermatitis; faf2; FAF2_HUMAN; Fas associated factor family member 2; FAS-associated factor 2; KIAA0887; Protein ETEA; Protein expressed in T cells and eosinophils in atopic dermatitis; Protein expressed in T-cells and eosinophils in atopic dermatitis; UBX domain containing 8; UBX domain protein 3B; UBX domain-containing protein 3B; UBX domain-containing protein 8; UBXD8; UBXN3B;
Immunogens
- Q96CS3 FAF2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE
PTMs - Q96CS3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T10 | Phosphorylation | Uniprot | |
| T14 | Phosphorylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| K167 | Acetylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| T244 | Phosphorylation | Uniprot | |
| Y297 | Phosphorylation | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| K400 | Ubiquitination | Uniprot |
Research Backgrounds
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.
Cytoplasm. Lipid droplet. Endoplasmic reticulum.
Broadly expressed, with highest levels in brain.
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. Interacts (via N-terminus) with UBQLN2 (via C-terminus). Interacts with PNPLA2 and UBAC2. Interacts with ZFAND2B; probably through VCP. Interacts with LMBR1L.
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