AFfirm™ TMBIM6 Mouse Monoclonal Antibody - #BF8783

Product: TMBIM6 Mouse Monoclonal Antibody
Catalog: BF8783
Description: Mouse monoclonal antibody to TMBIM6
Application: WB
Reactivity: Human
Prediction: Mouse, Rat
Mol.Wt.: 30kD; 27kD(Calculated).
Uniprot: P55061

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8783]
Specificity:
TMBIM6 Mouse Monoclonal Antibody detects endogenous levels of TMBIM6.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Bax inhibitor 1; BI 1; BI-1; BI1; BI1_HUMAN; TEGT; testis enhanced gene transcript (BAX inhibitor 1); Testis enhanced gene transcript; Testis-enhanced gene transcript protein; TMBIM 6; TMBIM6; Transmembrane BAX inhibitor motif containing 6; Transmembrane BAX inhibitor motif containing protein 6; Transmembrane BAX inhibitor motif-containing protein 6;

Immunogens

Immunogen:

A synthesized peptide derived from human TMBIM6.

Uniprot:

P55061(BI1_HUMAN) >>Visit HPA database.

Gene(ID):
TMBIM6(7009)
Expression:
P55061 BI1_HUMAN:

Highly abundant in testis.

Sequence:
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK

Research Backgrounds

Function:

Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).

Subcellular Location:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly abundant in testis.

Subunit Structure:

Interacts with BCL2 and BCL2L1.

Family&Domains:

The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.

Belongs to the BI1 family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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