AFfirm™ GATAD2A Mouse Monoclonal Antibody - #BF8703

Product: GATAD2A Mouse Monoclonal Antibody
Catalog: BF8703
Description: Mouse monoclonal antibody to GATAD2A
Application: WB
Reactivity: Human
Prediction: Mouse
Mol.Wt.: 68kD(Calculated).
Uniprot: Q86YP4

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8703]
Specificity:
GATAD2A Mouse Monoclonal Antibody detects endogenous levels of GATAD2A.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FLJ20085; FLJ21017; GATA zinc finger domain containing 2A; GATA zinc finger domain containing protein 2A; GATA zinc finger domain-containing protein 2A; GATAD2A; Hp66 alpha; Hp66alpha; OTTHUMP00000201911; OTTHUMP00000201912; P66 alpha; P66A_HUMAN; p66alpha; Transcriptional repressor p66 alpha; Transcriptional repressor p66-alpha; Transcriptional repressor p66alpha;

Immunogens

Immunogen:

A synthesized peptide derived from human GATAD2A.

Uniprot:

Q86YP4(P66A_HUMAN) >>Visit HPA database.

Gene(ID):
GATAD2A(54815)
Expression:
Q86YP4 P66A_HUMAN:

Ubiquitous, both in fetal and adult tissues.

Sequence:
MTEEACRTRSQKRALERDPTEDDVESKKIKMERGLLASDLNTDGDMRVTPEPGAGPTQGLLRATEATAMAMGRGEGLVGDGPVDMRTSHSDMKSERRPPSPDVIVLSDNEQPSSPRVNGLTTVALKETSTEALMKSSPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATAQKPTGSVGSTVTTPPPLVRGTQNIPAGKPSLQTSSARMPGSVIPPPLVRGGQQASSKLGPQASSQVVMPPLVRGAQQIHSIRQHSSTGPPPLLLAPRASVPSVQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTPASLKGTTATSAQANSTPTSVASVVTSAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNLLETQGRMSAATVLSREPYMCAQCKTDFTCRWREEKSGAIMCENCMTTNQKKALKVEHTSRLKAAFVKALQQEQEIEQRLLQQGTAPAQAKAEPTAAPHPVLKQVIKPRRKLAFRSGEARDWSNGAVLQASSQLSRGSATTPRGVLHTFSPSPKLQNSASATALVSRTGRHSERTVSAGKGSATSNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQSATWK

Research Backgrounds

Function:

Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.

Subcellular Location:

Nucleus speckle.
Note: Speckled nuclear localization requires both CR1 and CR2 regions.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous, both in fetal and adult tissues.

Subunit Structure:

Interacts with MBD2 and MBD3. Interaction with MBD2 is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin. Component of the MeCP1 histone deacetylase complex. Interacts with histone tails, including that of histones H2A, H2B, H3 and H4. This interaction is reduced by histone acetylation. Interacts with ERCC6.

Family&Domains:

Both CR1 and CR2 regions are required for speckled nuclear localization.

Restrictive clause

 

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