AFfirm™ GUCA1A Mouse Monoclonal Antibody - #BF8693

Product: GUCA1A Mouse Monoclonal Antibody
Catalog: BF8693
Description: Mouse monoclonal antibody to GUCA1A
Application: WB
Reactivity: Human
Prediction: Mouse
Mol.Wt.: 23kD(Calculated).
Uniprot: P43080

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8693]
Specificity:
GUCA1A Mouse Monoclonal Antibody detects endogenous levels of GUCA1A.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

COD3; GCAP 1; GCAP; Guanylate Cyclase Activating Protein Photoreceptor 1; Guanylate cyclase activator 1A; Guanylin 1; guanylyl cyclase activating protein 1; Guanylyl cyclase-activating protein 1; GUC1A_HUMAN; GUCA; GUCA1; GUCA1A;

Immunogens

Immunogen:

A synthesized peptide derived from human GUCA1A.

Uniprot:

P43080(GUC1A_HUMAN) >>Visit HPA database.

Gene(ID):
GUCA1A(2978)
Expression:
P43080 GUC1A_HUMAN:

Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.

Sequence:
MGNVMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIQAIRAINPCSDTTMTAEEFTDTVFSKIDVNGDGELSLEEFIEGVQKDQMLLDTLTRSLDLTRIVRRLQNGEQDEEGADEAAEAAG

Research Backgrounds

Function:

Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity).

Subcellular Location:

Membrane>Lipid-anchor. Cell projection>Cilium>Photoreceptor outer segment.
Note: Subcellular location is not affected by light or dark conditions.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.

Family&Domains:

Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high. Binds Mg(2+) when calcium levels are low.

Research Fields

· Organismal Systems > Sensory system > Phototransduction.

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