AFfirm™ SCNM1 Mouse Monoclonal Antibody - #BF8652
Product Info
Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Clonality:
Monoclonal [AFfirm8652]
Specificity:
SCNM1 Mouse Monoclonal Antibody detects endogenous levels of total SCNM1.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
SCNM 1; Sodium channel modifier 1;
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Sequence:
- Q9BWG6 SCNM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKQPGKERKQNPKHQNELRREETKAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPGPSVSLSPMPPSEVKLQSGKISREPEPAAGPQAEESATVSAPAPMSPTRRRALDHYLTLRSSGWIPDGRGRWVKDENVEFDSDEEEPPDLPLD
PTMs - Q9BWG6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| T195 | Phosphorylation | Uniprot | |
| S219 | Phosphorylation | Uniprot |
Research Backgrounds
Function:
Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
Subcellular Location:
Nucleus>Nucleoplasm. Nucleus speckle.
Note: Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.
Subunit Structure:
Interacts with spliceosomal Sm proteins. Interacts with LUC7L2 and SNRNP70, which suggests a role as a spliceosome component (By similarity).
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For Research Use Only.
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