AFfirm™ SCML2 Mouse Monoclonal Antibody - #BF8651
Product Info
Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Clonality:
Monoclonal [AFfirm8651]
Specificity:
SCML2 Mouse Monoclonal Antibody detects endogenous levels of total SCML2.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
SCML2; SCML2_HUMAN; sex comb on midleg like 2 (Drosophila); Sex comb on midleg like 2; Sex comb on midleg like protein 2; Sex comb on midleg, Drosophila, homolog-like 2; Sex comb on midleg-like protein 2;
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Expression:
Q9UQR0 SCML2_HUMAN:
Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.
Sequence:
- Q9UQR0 SCML2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGQTVNEDSMDVKKENQEKTPQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTESSPSEASQHSMQSPQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLPVICSTSAASLKSLTRDRGMLYKDVASGPCKIVMSTVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRGGEVITASFDGETHSIQLPPVNSASFALRFLENFCHSLQCDNLLSSQPFSSSRGHTHSSAEHDKNQSAKEDVTERQSTKRSPQQTVPYVVPLSPKLPKTKEYASEGEPLFAGGSAIPKEENLSEDSKSSSLNSGNYLNPACRNPMYIHTSVSQDFSRSVPGTTSSPLVGDISPKSSPHEVKFQMQRKSEAPSYIAVPDPSVLKQGFSKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKEGKYS
PTMs - Q9UQR0 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S9 | Phosphorylation | Uniprot | |
| K13 | Sumoylation | Uniprot | |
| K19 | Ubiquitination | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| K123 | Methylation | Uniprot | |
| K161 | Sumoylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K177 | Sumoylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K184 | Sumoylation | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K252 | Sumoylation | Uniprot | |
| T253 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| S264 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| K296 | Acetylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| T305 | Phosphorylation | P24941 (CDK2) , P06493 (CDK1) | Uniprot |
| K318 | Sumoylation | Uniprot | |
| T326 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| K407 | Acetylation | Uniprot | |
| K482 | Acetylation | Uniprot | |
| K487 | Sumoylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| T496 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| Y506 | Phosphorylation | Uniprot | |
| S511 | Phosphorylation | P24941 (CDK2) , P06493 (CDK1) | Uniprot |
| K518 | Ubiquitination | Uniprot | |
| Y520 | Phosphorylation | Uniprot | |
| S522 | Phosphorylation | Uniprot | |
| K536 | Sumoylation | Uniprot | |
| K536 | Ubiquitination | Uniprot | |
| K545 | Sumoylation | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| T567 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| T581 | Phosphorylation | Uniprot | |
| S582 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S590 | Phosphorylation | P06493 (CDK1) , P24941 (CDK2) | Uniprot |
| S593 | Phosphorylation | Uniprot | |
| S594 | Phosphorylation | Uniprot | |
| K599 | Sumoylation | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| K605 | Sumoylation | Uniprot | |
| K605 | Ubiquitination | Uniprot | |
| S606 | Phosphorylation | Uniprot | |
| K621 | Ubiquitination | Uniprot | |
| K663 | Ubiquitination | Uniprot | |
| S670 | Phosphorylation | Uniprot | |
| K680 | Sumoylation | Uniprot |
Research Backgrounds
Function:
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.
Family&Domains:
Belongs to the SCM family.
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