AFfirm™ CHST5 Mouse Monoclonal Antibody - #BF8643
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
Carbohydrate (N acetylglucosamine 6 O) sulfotransferase 5; Carbohydrate sulfotransferase 5; Chst5; CHST5_HUMAN; FLJ22167; Galactose/N acetylglucosamine/N acetylglucosamine 6 O sulfotransferase 4 alpha; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha; GlcNAc6ST 3; GlcNAc6ST-3; Gn6st-3; GST4 alpha; GST4-alpha; hIGn6ST; I GlcNAc 6 ST; I GlcNAc6ST; I-GlcNAc6ST; IGlcNAc6ST; Intestinal GlcNAc 6 sulfotransferase; Intestinal GlcNAc-6-sulfotransferase; Intestinal GlcNAcv6 sulfotransferase; Intestinal N acetylglucosamine 6 O sulfotransferase; Intestinal N-acetylglucosamine-6-O-sulfotransferase; MGC74625; N acetylglucosamine 6 O sulfotransferase 3; N acetylglucosamine 6 O sulfotransferase; N-acetylglucosamine 6-O-sulfotransferase 3; OTTHUMP00000174950;
Immunogens
Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas.
- Q9GZS9 CHST5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGMRARVPKVAHSTRRPPAARMWLPRFSSKTVTVLLLAQTTCLLLFIISRPGPSSPAGGEDRVHVLVLSSWRSGSSFLGQLFSQHPDVFYLMEPAWHVWTTLSQGSAATLHMAVRDLMRSIFLCDMDVFDAYMPQSRNLSAFFNWATSRALCSPPACSAFPRGTISKQDVCKTLCTRQPFSLAREACRSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREAAGPILARDNGIVLGTNGKWVEADPHLRLIREVCRSHVRIAEAATLKPPPFLRGRYRLVRFEDLAREPLAEIRALYAFTGLTLTPQLEAWIHNITHGSGIGKPIEAFHTSSRNARNVSQAWRHALPFTKILRVQEVCAGALQLLGYRPVYSADQQRDLTLDLVLPRGPDHFSWASPD
PTMs - Q9GZS9 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S181 | Phosphorylation | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| Y190 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot |
Research Backgrounds
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.
Golgi apparatus membrane>Single-pass type II membrane protein.
Note: Golgi membrane, early secretory pathway.
Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas.
Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
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