AFfirm™ ALS2 Mouse Monoclonal Antibody - #BF8641
Product Info
Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Clonality:
Monoclonal [AFfirm8641]
Specificity:
ALS2 Mouse Monoclonal Antibody detects endogenous levels of total ALS2.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
ALS 2; ALS2; ALS2_HUMAN; ALS2CR6; Alsin; ALSJ; Amyotrophic lateral sclerosis 2 (juvenile); Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 6; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; Amyotrophic lateral sclerosis 2 protein; Amyotrophic lateral sclerosis protein 2; FLJ31851; IAHSP; KIAA1563; MGC87187; PLSJ;
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Sequence:
- Q96Q42 ALS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN
PTMs - Q96Q42 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T31 | Phosphorylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| S356 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| R481 | Methylation | Uniprot | |
| S483 | Phosphorylation | Uniprot | |
| S489 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| T510 | Phosphorylation | Uniprot | |
| T526 | Phosphorylation | Uniprot | |
| T530 | Phosphorylation | Uniprot | |
| K533 | Acetylation | Uniprot | |
| K677 | Ubiquitination | Uniprot | |
| S714 | Phosphorylation | Uniprot | |
| K849 | Ubiquitination | Uniprot | |
| K993 | Ubiquitination | Uniprot | |
| Y1039 | Phosphorylation | Uniprot | |
| S1055 | Phosphorylation | Uniprot | |
| K1057 | Ubiquitination | Uniprot | |
| Y1084 | Phosphorylation | Uniprot | |
| K1160 | Ubiquitination | Uniprot | |
| K1281 | Acetylation | Uniprot | |
| K1292 | Acetylation | Uniprot | |
| S1335 | Phosphorylation | Uniprot | |
| S1342 | Phosphorylation | Uniprot | |
| T1344 | Phosphorylation | Uniprot | |
| S1349 | Phosphorylation | Uniprot | |
| Y1394 | Phosphorylation | Uniprot | |
| Y1398 | Phosphorylation | Uniprot | |
| S1452 | Phosphorylation | Uniprot | |
| S1458 | Phosphorylation | Uniprot | |
| S1460 | Phosphorylation | Uniprot | |
| S1462 | Phosphorylation | Uniprot | |
| S1464 | Phosphorylation | Uniprot | |
| Y1469 | Phosphorylation | Uniprot |
Research Backgrounds
Function:
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity).
Subunit Structure:
Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL.
Research Fields
· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).
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