AFfirm™ Uroplakin III Mouse Monoclonal Antibody - #BF8629

Product: Uroplakin III Mouse Monoclonal Antibody
Catalog: BF8629
Description: Mouse monoclonal antibody to Uroplakin III
Application: WB
Reactivity: Human
Prediction: Mouse
Mol.Wt.: 31kD(Calculated).
Uniprot: O75631

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8629]
Specificity:
Uroplakin III Mouse Monoclonal Antibody detects endogenous levels of total Uroplakin III.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

MGC119178; OTTHUMP00000028951; UP III; UP3a; UPIII; UPIIIA; UPK 3; UPK 3A; UPK3; UPK3A; UPK3A_HUMAN; Uroplakin 3A; Uroplakin III; Uroplakin-3a; Uroplakin3A; UroplakinIII;

Immunogens

Immunogen:

A synthesized peptide derived from Human Uroplakin III.

Uniprot:

O75631(UPK3A_HUMAN) >>Visit HPA database.

Gene(ID):
UPK3A(7380)
Expression:
O75631 UPK3A_HUMAN:

Expressed in ureter.

Sequence:
MPPLWALLALGCLRFGSAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD

Research Backgrounds

Function:

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

Subcellular Location:

Endoplasmic reticulum membrane>Single-pass type I membrane protein.
Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in ureter.

Subunit Structure:

Heterodimer with uroplakin-1B (UPK1B).

Family&Domains:

Belongs to the uroplakin-3 family.

Research Fields

· Human Diseases > Cancers: Specific types > Bladder cancer.   (View pathway)

Restrictive clause

 

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