AFfirm™ MURC Mouse Monoclonal Antibody - #BF8584

Product: MURC Mouse Monoclonal Antibody
Catalog: BF8584
Description: Mouse monoclonal antibody to MURC
Application: WB
Reactivity: Human
Mol.Wt.: 37~50kD; 42kD(Calculated).
Uniprot: Q5BKX8

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8584]
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

murC; MURC_HUMAN; Muscle-related coiled-coil protein; Muscle-restricted coiled-coil protein;

Immunogens

Immunogen:

A synthesized peptide derived from Human MURC.

Uniprot:

Q5BKX8(CAVN4_HUMAN) >>Visit HPA database.

Gene(ID):
CAVIN4(347273)
Sequence:
MEHNGSASNADKIHQNRLSSVTEDEDQDAALTIVTVLDKVASIVDSVQASQKRIEERHREMENAIKSVQIDLLKLSQSHSNTGHIINKLFEKTRKVSAHIKDVKARVEKQQIHVKKVEVKQEEIMKKNKFRVVIFQEKFRCPTSLSVVKDRNLTENQEEDDDDIFDPPVDLSSDEEYYVEESRSARLRKSGKEHIDNIKKAFSKENMQKTRQNLDKKVNRIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNAAPSKEAFKMRSLRKGKDRTVAEGEECAREMGVDIIARSESLGPISELYSDELSEPEHEAARPVYPPHEGREIPTPEPLKVTFKSQVKVEDDESLLLDLKHSS

Research Backgrounds

Function:

Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.

Subcellular Location:

Cytoplasm>Myofibril>Sarcomere. Cytoplasm. Cytoplasm>Cytosol. Cell membrane>Sarcolemma. Membrane>Caveola. Cell membrane.
Note: In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4 (By similarity). Interacts with CAVIN1, ADRA1A and ADRA1B. Interacts with CAVIN2; this augments the transactivation of NPPA. Interacts with CAV3. Interacts with MAPK1 and MAPK3 (By similarity).

Family&Domains:

The coiled coil domain (residues 44-77) is essential for membrane-targeting in cardiomyocytes.

Belongs to the CAVIN family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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