AFfirm™ DCL-1 Mouse Monoclonal Antibody - #BF8459
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
BIMLEC; C type lectin BIMLEC; C type lectin domain family 13 member A; C-type lectin BIMLEC; C-type lectin domain family 13 member A; CD302; CD302 antigen; CD302_HUMAN; CLEC13A; DCL1; KIAA0022; Type I transmembrane C type lectin receptor DCL-1; Type I transmembrane C-type lectin receptor DCL-1;
Immunogens
Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
- Q8IX05 CD302_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLRAALPALLLPLLGLAAAAVADCPSSTWIQFQDSCYIFLQEAIKVESIEDVRNQCTDHGADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDDASFKWFDNSNMTFDKWTDQDDDEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYKRKYLSDNHILISALVIASTVILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCVLVVGEENEYPVQFD
PTMs - Q8IX05 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S101 | Phosphorylation | Uniprot | |
| K140 | Methylation | Uniprot |
Research Backgrounds
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
May be heterogeneously N-glycosylated in some cell types.
Membrane>Single-pass type I membrane protein. Cell projection>Filopodium. Cytoplasm>Cell cortex. Cell projection>Microvillus.
Note: Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
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