AFfirm™ SOD2/MnSOD Mouse Monoclonal Antibody - #BF8397
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
Indophenoloxidase B; IPO B; IPOB; Manganese containing superoxide dismutase; Manganese SOD; Manganese superoxide dismutase; Mangano superoxide dismutase; Mn SOD; Mn superoxide dismutase; MNSOD; MVCD6; SOD 2; SOD2; SODM_HUMAN; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn], mitochondrial; Superoxide dismutase 2 mitochondrial;
Immunogens
- P04179 SODM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
PTMs - P04179 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K53 | Acetylation | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| K68 | Acetylation | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | P06493 (CDK1) , P11802 (CDK4) | Uniprot |
| K122 | Acetylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| K130 | Acetylation | Uniprot | |
| K130 | Methylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| K132 | Acetylation | Uniprot | |
| K221 | Acetylation | Uniprot |
Research Backgrounds
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.
Mitochondrion matrix.
Homotetramer.
Belongs to the iron/manganese superoxide dismutase family.
Research Fields
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Organismal Systems > Aging > Longevity regulating pathway. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway - multiple species. (View pathway)
Restrictive clause
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For Research Use Only.
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