AFfirm™ KCNH2 Mouse Monoclonal Antibody - #BF8383
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*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
eag homolog; Eag-related protein 1; ERG; ERG-1; ERG1; Ether a go go related potassium channel protein; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go-related protein 1; H ERG; H-ERG; HERG 1; HERG; hERG-1; hERG1; KCNH2; KCNH2_HUMAN; Kv11.1; LQT 2; LQT2; Potassium channel HERG; Potassium voltage gated channel subfamily H (eag related) member 2; Potassium voltage-gated channel subfamily H member 2; SQT1; Voltage gated potassium channel, subfamily H, member 2; Voltage-gated potassium channel subunit Kv11.1;
Immunogens
Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
- Q12809 KCNH2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS
PTMs - Q12809 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K166 | Ubiquitination | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S284 | Phosphorylation | Uniprot | |
| T305 | Phosphorylation | Uniprot | |
| T319 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| Y388 | Phosphorylation | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| Y475 | Phosphorylation | Uniprot | |
| N598 | N-Glycosylation | Uniprot | |
| Y611 | Phosphorylation | Uniprot | |
| K741 | Ubiquitination | Uniprot | |
| Y780 | Phosphorylation | Uniprot | |
| Y827 | Phosphorylation | Uniprot | |
| S871 | Phosphorylation | Uniprot | |
| S882 | Phosphorylation | Uniprot | |
| S890 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| T895 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| Y1009 | Phosphorylation | Uniprot | |
| S1029 | Phosphorylation | Uniprot | |
| S1137 | Phosphorylation | P17612 (PRKACA) | Uniprot |
Research Backgrounds
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
Cell membrane>Multi-pass membrane protein.
Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Interacts with DNAJB12 and DNAJB14; chaperones DNAJB12 and DNAJB14 promote tetramerization. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3 (By similarity). Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2. Interacts with CANX. The core-glycosylated, but not the fully glycosylated form interacts with RNF207. Interacts with NDFIP1 and NDFIP2.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
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