AFfirm™ FRA2 Mouse Monoclonal Antibody - #BF8276
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Product Info
Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human,Mouse,Rat
Clonality:
Monoclonal [AFfirm8276]
Specificity:
FRA2 Mouse Monoclonal Antibody detects endogenous levels of total FRA2
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
FLJ23306; Fos L2; FOS like antigen 2; Fos related antigen 2; Fos-related antigen 2; FosL 2; Fosl2; FOSL2_HUMAN; FRA 2; FRA-2;
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Description:
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts.
Sequence:
- P15408 FOSL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSGSAFIPTINAITTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRRRRDEQLSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKLEFMLVAHGPVCKISPEERRSPPAPGLQPMRSGGGSVGAVVVKQEPLEEDSPSSSSAGLDKAQRSVIKPISIAGGFYGEEPLHTPIVVTSTPAVTPGTSNLVFTYPSVLEQESPASPSESCSKAHRRSSSSGDQSSDSLNSPTLLAL
PTMs - P15408 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| Y2 | Phosphorylation | Uniprot | |
| Y5 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| K104 | Acetylation | Uniprot | |
| K104 | Methylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S200 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| K222 | Acetylation | Uniprot | |
| K222 | Sumoylation | Uniprot | |
| S230 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S317 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| T322 | Phosphorylation | Uniprot |
Research Backgrounds
Function:
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
Subcellular Location:
Nucleus.
Subunit Structure:
Heterodimer.
Family&Domains:
Belongs to the bZIP family. Fos subfamily.
Research Fields
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
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For Research Use Only.
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