AFfirm™ GAB1 Mouse Monoclonal Antibody - #BF8193
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
Gab 1; GAB1; GAB1_HUMAN; GRB 2 associated binder 1; GRB 2 associated binding protein 1; GRB2 associated binding protein 1 isoform a; GRB2 associated binding protein 1 isoform b; GRB2-associated binder 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1;
Immunogens
- Q13480 GAB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
PTMs - Q13480 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| Y48 | Phosphorylation | Uniprot | |
| Y83 | Phosphorylation | Uniprot | |
| Y183 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| C213 | S-Nitrosylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| Y242 | Phosphorylation | P12931 (SRC) , P06213 (INSR) | Uniprot |
| S244 | Phosphorylation | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| S253 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| Y259 | Phosphorylation | P12931 (SRC) | Uniprot |
| Y265 | Phosphorylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| Y285 | Phosphorylation | P00533 (EGFR) , P06213 (INSR) , P08581 (MET) | Uniprot |
| S304 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| Y307 | Phosphorylation | P00533 (EGFR) , P08581 (MET) | Uniprot |
| T312 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| T316 | Phosphorylation | Uniprot | |
| Y317 | Phosphorylation | P12931 (SRC) | Uniprot |
| S355 | Phosphorylation | Uniprot | |
| T365 | Phosphorylation | Uniprot | |
| S367 | Phosphorylation | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| Y373 | Phosphorylation | P08581 (MET) , P06213 (INSR) , P00533 (EGFR) , P12931 (SRC) | Uniprot |
| S381 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S383 | Phosphorylation | Uniprot | |
| T387 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| Y406 | Phosphorylation | P00533 (EGFR) , P08581 (MET) | Uniprot |
| S417 | Phosphorylation | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| Y447 | Phosphorylation | P06213 (INSR) , P08581 (MET) , P00533 (EGFR) | Uniprot |
| S454 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y472 | Phosphorylation | P00533 (EGFR) , P06213 (INSR) , P08581 (MET) | Uniprot |
| T476 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S500 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| S582 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y589 | Phosphorylation | P06213 (INSR) , P00533 (EGFR) , P08581 (MET) | Uniprot |
| S597 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y627 | Phosphorylation | P06213 (INSR) , P12931 (SRC) , P08581 (MET) , P09619 (PDGFRB) , P00533 (EGFR) | Uniprot |
| S634 | Phosphorylation | Uniprot | |
| S637 | Phosphorylation | Uniprot | |
| T638 | Phosphorylation | Uniprot | |
| S645 | Phosphorylation | Uniprot | |
| S651 | Phosphorylation | Uniprot | |
| Y659 | Phosphorylation | P08581 (MET) , P06213 (INSR) , P00533 (EGFR) , P09619 (PDGFRB) | Uniprot |
| T673 | Phosphorylation | Uniprot | |
| S683 | Phosphorylation | Uniprot | |
| T684 | Phosphorylation | Uniprot |
Research Backgrounds
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway.
Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Part of a tripartite complex containing GAB1, METTL13 and SPRY2. Interacts with METTL13.
Belongs to the GAB family.
Research Fields
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Ras signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > EGFR tyrosine kinase inhibitor resistance.
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Cancers: Specific types > Renal cell carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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