AFfirm™ SFRS16 Mouse Monoclonal Antibody - #BF8109
(2)
Product Info
Source:
Mouse
Application:
WB 1:1000-1:10000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Clonality:
Monoclonal [AFfirm8109]
Specificity:
SFRS16 Antibody detects endogenous levels of total SFRS16.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
CLASP; CLK4 associating serine/arginine rich protein; Clk4 associating SR related protein; FLJ90109; SFRS16; Splicing factor, arginine/serine rich 16 (suppressor of white apricot homolog, Drosophila); Splicing factor, arginine/serine rich 16; Suppressor of white apricot homolog 2; SWAP2;
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Sequence:
- Q8N2M8 CLASR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAKVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH
PTMs - Q8N2M8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R13 | Methylation | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| Y228 | Phosphorylation | Uniprot | |
| K259 | Sumoylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| T296 | Phosphorylation | Uniprot | |
| Y297 | Phosphorylation | Uniprot | |
| Y300 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| S317 | Phosphorylation | Uniprot | |
| T319 | Phosphorylation | Uniprot | |
| T327 | Phosphorylation | Uniprot | |
| T330 | Phosphorylation | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| T389 | Phosphorylation | Uniprot | |
| S390 | Phosphorylation | Uniprot | |
| S391 | Phosphorylation | Uniprot | |
| S394 | Phosphorylation | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| Y432 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S456 | Phosphorylation | Uniprot | |
| R460 | Methylation | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| S497 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| S505 | Phosphorylation | Uniprot | |
| S511 | Phosphorylation | Uniprot | |
| S515 | Phosphorylation | Uniprot | |
| S521 | Phosphorylation | Uniprot | |
| S531 | Phosphorylation | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| S535 | Phosphorylation | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| K556 | Acetylation | Uniprot | |
| K556 | Sumoylation | Uniprot | |
| K563 | Acetylation | Uniprot | |
| K571 | Sumoylation | Uniprot | |
| T573 | Phosphorylation | Uniprot | |
| S642 | Phosphorylation | Uniprot | |
| S645 | Phosphorylation | Uniprot | |
| S647 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| Y652 | Phosphorylation | Uniprot |
Research Backgrounds
Function:
Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).
PTMs:
Phosphorylated in vitro by CLK4.
Subcellular Location:
Nucleus.
Subunit Structure:
Probably interacts with CLK4.
Family&Domains:
Belongs to the splicing factor SR family.
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