AFfirm™ SLC9A2 Mouse Monoclonal Antibody - #BF8116
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
H7; Na(+)/H(+) exchanger 2; NHE 2; NHE-2; NHE2; SL9A2_HUMAN; Slc9a2; Sodium/hydrogen exchanger; Sodium/hydrogen exchanger 2; Solute carrier family 9 (sodium/hydrogen exchanger), member 2; Solute carrier family 9 member 2; Solute carrier family 9, member 2;
Immunogens
Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.
- Q9UBY0 SL9A2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
PTMs - Q9UBY0 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y356 | Phosphorylation | Uniprot | |
| Y361 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| Y503 | Phosphorylation | Uniprot | |
| K536 | Ubiquitination | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| Y610 | Phosphorylation | Uniprot | |
| S623 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| S647 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| T662 | Phosphorylation | Uniprot | |
| S665 | Phosphorylation | Uniprot | |
| Y667 | Phosphorylation | Uniprot | |
| S669 | Phosphorylation | Uniprot | |
| T674 | Phosphorylation | Uniprot | |
| K679 | Acetylation | Uniprot | |
| S739 | Phosphorylation | Uniprot | |
| S745 | Phosphorylation | Uniprot | |
| T746 | Phosphorylation | Uniprot | |
| T749 | Phosphorylation | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| T757 | Phosphorylation | Uniprot |
Research Backgrounds
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
Phosphorylated (Possible).
Membrane>Multi-pass membrane protein.
Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.
Interacts with CHP1 and CHP2.
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
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