AFfirm™ PGRMC1 Mouse Monoclonal Antibody - #BF8084
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
HPR6.6; Membrane associated progesterone receptor component 1; Membrane-associated progesterone receptor component 1; mPR; PGRC1_HUMAN; PGRMC; Pgrmc1; Progesterone binding protein; Progesterone receptor membrane component 1;
Immunogens
A synthesized peptide derived from human PGRMC1, corresponding to a region within C-terminal amino acids.
- O00264 PGRC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND
PTMs - O00264 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R47 | Methylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| T74 | Phosphorylation | Uniprot | |
| R79 | Methylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| T101 | Phosphorylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| Y107 | Phosphorylation | Uniprot | |
| Y113 | Phosphorylation | Uniprot | |
| R119 | Methylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| T152 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K172 | Ubiquitination | Uniprot | |
| T178 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| S190 | Phosphorylation | Uniprot |
Research Backgrounds
Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs).
Microsome membrane>Single-pass membrane protein. Smooth endoplasmic reticulum membrane>Single-pass membrane protein.
Widely expressed, with highest expression in liver and kidney.
Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.
The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
Belongs to the cytochrome b5 family. MAPR subfamily.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.