AFfirm™ MAGE 1 Mouse Monoclonal Antibody - #BF8046
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
Antigen MZ2 E; Antigen MZ2-E; Cancer/testis antigen 1.1; cancer/testis antigen family 1, member 1; CT1.1; MAGA1_HUMAN; MAGE 1 antigen; MAGE-1 antigen; MAGE1; MAGE1A; MAGEA1; Melanoma antigen 1; Melanoma antigen family A 1 (directs expression of antigen MZ2 E); Melanoma antigen family A 1; Melanoma antigen MAGE 1; Melanoma associated antigen 1; Melanoma associated antigen MZ2 E; Melanoma-associated antigen 1; MGC9326;
Immunogens
A synthesized peptide derived from human MAGE 1, corresponding to a region within C-terminal amino acids.
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
- P43355 MAGA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREAALREEEEGV
PTMs - P43355 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S57 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| K160 | Acetylation | Uniprot | |
| K237 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| Y251 | Phosphorylation | Uniprot | |
| Y276 | Phosphorylation | Uniprot | |
| K278 | Methylation | Uniprot | |
| K278 | Ubiquitination | Uniprot |
Research Backgrounds
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Cytoplasm. Nucleus.
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
Interacts with SNW1 and HDCA1.
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