Product: SIGLEC15 Mouse Monoclonal Antibody
Catalog: BF8008
Source: Mouse
Application: IHC, IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 36kD(Calculated).
Uniprot: Q6ZMC9

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 50ul $250 In stock
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Product Info

Source:
Mouse
Application:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Monoclonal [AFfirm8008(AFB19405)]
Specificity:
SIGLEC15 Mouse Monoclonal Antibody detects endogenous levels of total SIGLEC15.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CD33 antigen-like 3;CD33 molecule-like 3;CD33L3;HsT1361;Sialic acid-binding Ig-like lectin 15;SIG15_HUMAN;Siglec-15;SIGLEC15;

Immunogens

Immunogen:

A synthesized peptide derived from human SIGLEC15.

Uniprot:
Gene(ID):
Expression:
Q6ZMC9 SIG15_HUMAN:

Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

Sequence:
MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRWSMQVPPEVSAEAGDAAVLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNPRRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNISVLPSPAHAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAANSLGRSEASVYLFRFHGASGASTVALLLGALGFKALLLLGVLAARAARRRPEHLDTPDTPPRSQAQESNYENLSQMNPRSPPATMCSP

Research Backgrounds

Function:

Binds sialylated glycoproteins.

Subcellular Location:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

Subunit Structure:

Interacts with TYROBP and HCST.

Family&Domains:

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

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