SENP6 Antibody - #AF0277
Product: | SENP6 Antibody |
Catalog: | AF0277 |
Description: | Rabbit polyclonal antibody to SENP6 |
Application: | WB IHC |
Reactivity: | Human, Mouse |
Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
Mol.Wt.: | 126kDa; 126kD(Calculated). |
Uniprot: | Q9GZR1 |
RRID: | AB_2834163 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0277, RRID:AB_2834163.
Fold/Unfold
2810017C20Rik; FLJ11355; FLJ11887; KIAA0389; KIAA0797; SENP 6; Senp6; SENP6_HUMAN; Sentrin specific protease 6; Sentrin-specific protease 6; Sentrin/SUMO specific protease SENP6; Sentrin/SUMO-specific protease SENP6; SSP 1; SSP1; SUMO 1 specific protease 1; SUMO 1 specific protease; SUMO-1-specific protease 1; SUMO1 specific protease 1; SUMO1 specific protease; SUMO1/sentrin specific peptidase 6; SUSP 1; SUSP1;
Immunogens
- Q9GZR1 SENP6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAGKSGGSAGEITFLEALARSESKRDGGFKNNWSFDHEEESEGDTDKDGTNLLSVDEDEDSETSKGKKLNRRSEIVANSSGEFILKTYVRRNKSESFKTLKGNPIGLNMLSNNKKLSENTQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQSSLDRKERKEYPPHVQKVEINPVRLSRLQGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQAITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKVPIDIIVNCDDSKHTYLQTNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSACSSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTLPRKARMKDQFGNSIINTPLKRRKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHDPVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKGVNKLTNLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVACTRTYEESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERRNHETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPKYEPNPHYHENAVIQKCSTVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDSNPGQEESDPRYKRNICSVKYSVKKINHTASENEEFNKGESTSQKVADRTKSENGLQNESLSSTHHTDGLSKIRLNYSDESPEAGKMLEDELVDFSEDQDNQDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQEDQSKEKRKHKDTYSTEAPLGEGTEQYVNSISD
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9GZR1 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S6 | Phosphorylation | Uniprot | |
S9 | Phosphorylation | Uniprot | |
S22 | Phosphorylation | Uniprot | |
S35 | Phosphorylation | Uniprot | |
S42 | Phosphorylation | Uniprot | |
S55 | Phosphorylation | Uniprot | |
K99 | Methylation | Uniprot | |
T100 | Phosphorylation | Uniprot | |
K102 | Methylation | Uniprot | |
K189 | Sumoylation | Uniprot | |
Y214 | Phosphorylation | Uniprot | |
T217 | Phosphorylation | Uniprot | |
S221 | Phosphorylation | Uniprot | |
S224 | Phosphorylation | Uniprot | |
K226 | Ubiquitination | Uniprot | |
K264 | Ubiquitination | Uniprot | |
K274 | Sumoylation | Uniprot | |
K319 | Ubiquitination | Uniprot | |
T323 | Phosphorylation | Uniprot | |
S335 | Phosphorylation | Uniprot | |
S336 | Phosphorylation | Uniprot | |
T345 | Phosphorylation | Uniprot | |
S350 | Phosphorylation | Uniprot | |
S352 | Phosphorylation | Uniprot | |
S361 | Phosphorylation | Uniprot | |
S362 | Phosphorylation | Uniprot | |
T398 | Phosphorylation | Uniprot | |
K406 | Sumoylation | Uniprot | |
S412 | Phosphorylation | Uniprot | |
T416 | Phosphorylation | Uniprot | |
K419 | Sumoylation | Uniprot | |
K534 | Ubiquitination | Uniprot | |
S577 | Phosphorylation | Uniprot | |
Y599 | Phosphorylation | Uniprot | |
S606 | Phosphorylation | Uniprot | |
K736 | Ubiquitination | Uniprot | |
S819 | Phosphorylation | Uniprot | |
S869 | Phosphorylation | Uniprot | |
K910 | Ubiquitination | Uniprot | |
S916 | Phosphorylation | Uniprot | |
S919 | Phosphorylation | Uniprot | |
S985 | Phosphorylation | Uniprot | |
K1086 | Ubiquitination | Uniprot | |
S1111 | Phosphorylation | Uniprot |
Research Backgrounds
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Nucleus.
Highly expressed in reproductive organs, such as testis, ovary and prostate.
Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.
Belongs to the peptidase C48 family.
References
Application: WB Species: Human Sample: HUVECs
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