FGFR1 Oncogene Partner Antibody - #AF0158

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Product: FGFR1 Oncogene Partner Antibody
Catalog: AF0158
Description: Rabbit polyclonal antibody to FGFR1 Oncogene Partner
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Rabbit, Dog
Mol.Wt.: 43kDa; 43kD(Calculated).
Uniprot: O95684
RRID: AB_2833339

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Rabbit(89%), Dog(100%)
Clonality:
Polyclonal
Specificity:
FGFR1 Oncogene Partner Antibody detects endogenous levels of total FGFR1 Oncogene Partner.
RRID:
AB_2833339
Cite Format: Affinity Biosciences Cat# AF0158, RRID:AB_2833339.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FGFR1 oncogene partner; FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN; OTTHUMP00000017612; OTTHUMP00000017613;

Immunogens

Immunogen:
Uniprot:

O95684(FR1OP_HUMAN) >>Visit HPA database.

Gene(ID):
FGFR1OP(11116)
Expression:
O95684 FR1OP_HUMAN:

Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.

Description:
FOP Required for anchoring microtubules to the centrosomes. Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1. 3 isoforms of the human protein are produced by alternative splicing.
Sequence:
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEGALDLSDVHSPPKSPEGKTSAQTTPSKIPRYKGQGKKKTSGQKAGDKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGEDDDYVDDFNSTSHRSEKSEISIGEEIEEDLSVEIDDINTSDKLDDLTQDLTVSQLSDVADYLEDVA

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Dog
100
Rabbit
89
Xenopus
78
Zebrafish
75
Chicken
67
Sheep
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O95684 As Substrate

Site PTM Type Enzyme
T4 Phosphorylation
T55 Phosphorylation
S61 Phosphorylation
K63 Ubiquitination
T143 Phosphorylation
S152 Phosphorylation
S156 Phosphorylation
S160 Phosphorylation
T165 Phosphorylation
T169 Phosphorylation
T170 Phosphorylation
S172 Phosphorylation
K182 Acetylation
K183 Acetylation
K184 Acetylation
S202 Phosphorylation
T204 Phosphorylation
S209 Phosphorylation
K214 Acetylation
S228 Phosphorylation
S231 Phosphorylation
T234 Phosphorylation
S254 Phosphorylation
T266 Phosphorylation
Y267 Phosphorylation
S279 Phosphorylation
S291 Phosphorylation
S301 Phosphorylation
K323 Ubiquitination
S326 Phosphorylation
Y337 Phosphorylation
S343 Phosphorylation
S348 Phosphorylation
S389 Phosphorylation
Y394 Phosphorylation

Research Backgrounds

Function:

Required for anchoring microtubules to the centrosomes. Required for ciliation.

Subcellular Location:

Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cytoplasm>Cytoskeleton>Cilium basal body.
Note: Associated with gamma-tubulin (PubMed:16314388). Localizes on both mother and daughter centrioles (PubMed:28625565, PubMed:28428259). Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole partly on the subdistal appendage region (PubMed:28659385).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.

Subunit Structure:

Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1. Interacts with CEP19. Interacts (via N-terminus) with CEP350 (via C-terminus).

Family&Domains:

Belongs to the FGFR1OP family.

Restrictive clause

 

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