GAS2L1 Antibody - #DF6866

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Product: GAS2L1 Antibody
Catalog: DF6866
Description: Rabbit polyclonal antibody to GAS2L1
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus
Mol.Wt.: 73kDa; 73kD(Calculated).
Uniprot: Q99501
RRID: AB_2838825

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(92%), Sheep(100%), Dog(100%), Chicken(83%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
GAS2L1 Antibody detects endogenous levels of total GAS2L1.
RRID:
AB_2838825
Cite Format: Affinity Biosciences Cat# DF6866, RRID:AB_2838825.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

GA2L1_HUMAN; GAR 22; GAR22; GAS2 like protein 1; GAS2 related protein on chromosome 22; GAS2-like protein 1; GAS2-related protein on chromosome 22; GAS2L1; Growth arrest specific 2 like 1; Growth arrest specific protein 2 like 1; Growth arrest-specific protein 2-like 1; MGC17243;

Immunogens

Immunogen:
Uniprot:

Q99501(GA2L1_HUMAN) >>Visit HPA database.

Gene(ID):
GAS2L1(10634)
Description:
The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Sequence:
MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAAARPARGVAFQAHSVVPGSFMARDNVATFIGWCRVELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIERELRAAPPAPNAPAAGEDTTETAPAPGTPARGPRMTPSDLRNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRGRPRGAPGGRGAQLSVPSPARRARSQSREEQAVLLVRRDRDGQHSWVPRGRGSGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASIFRTPLQLDPQQEQQLFRRLEEEFLANARALEAVASVTPTGPVPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGDSGRTANGLPGPRSQALSSSSDEGSPCPGMGGPLDAPGSPLACTEPSRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTWHALHSVTPRAEPDSWM

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Horse
92
Chicken
83
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q99501 As Substrate

Site PTM Type Enzyme
A2 Acetylation
S11 Phosphorylation
K14 Ubiquitination
T193 Phosphorylation
T220 Phosphorylation
S231 Phosphorylation
T290 Phosphorylation
S292 Phosphorylation
S297 Phosphorylation
T299 Phosphorylation
T300 Phosphorylation
S301 Phosphorylation
S306 Phosphorylation
S311 Phosphorylation
S316 Phosphorylation
T321 Phosphorylation
S324 Phosphorylation
T334 Phosphorylation
Y351 Phosphorylation
S352 Phosphorylation
S355 Phosphorylation
S358 Phosphorylation
S360 Phosphorylation
S384 Phosphorylation
T388 Phosphorylation
T389 Phosphorylation
T391 Phosphorylation
S394 Phosphorylation
R421 Methylation
S429 Phosphorylation
S436 Phosphorylation
S438 Phosphorylation
S456 Phosphorylation
S479 Phosphorylation
S486 Phosphorylation
S489 Phosphorylation
S490 Phosphorylation
S492 Phosphorylation
T498 Phosphorylation
T539 Phosphorylation
S558 Phosphorylation
S562 Phosphorylation
T586 Phosphorylation
S645 Phosphorylation
S657 Phosphorylation
T672 Phosphorylation

Research Backgrounds

Function:

Involved in the cross-linking of microtubules and microfilaments. Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers.

Subcellular Location:

Cytoplasm>Cytoskeleton. Cytoplasm>Cytoskeleton>Stress fiber.
Note: Colocalizes with the tips of microtubule plus ends.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with MAPRE1.

Family&Domains:

Belongs to the GAS2 family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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