SLC38A2 Antibody - #DF4673

(3)  
Product: SLC38A2 Antibody
Catalog: DF4673
Description: Rabbit polyclonal antibody to SLC38A2
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Horse, Rabbit, Dog
Mol.Wt.: 50 KD; 56kD(Calculated).
Uniprot: Q96QD8
RRID: AB_2837024

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Horse(88%), Rabbit(88%), Dog(88%)
Clonality:
Polyclonal
Specificity:
SLC38A2 Antibody detects endogenous levels of total SLC38A2.
RRID:
AB_2837024
Cite Format: Affinity Biosciences Cat# DF4673, RRID:AB_2837024.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Amino acid transporter 2; Amino acid transporter A2; ATA2; KIAA1382; PRO1068; Protein 40-9-1; S38A2_HUMAN; SAT2; Slc38a2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Solute carrier family 38 member 2; System A amino acid transporter; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2;

Immunogens

Immunogen:
Uniprot:

Q96QD8(S38A2_HUMAN) >>Visit HPA database.

Gene(ID):
SLC38A2(54407)
Expression:
Q96QD8 S38A2_HUMAN:

Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).

Sequence:
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
88
Dog
88
Rabbit
88
Pig
0
Bovine
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96QD8 As Substrate

Site PTM Type Enzyme
K2 Ubiquitination
K3 Ubiquitination
S10 Phosphorylation
S12 Phosphorylation
S17 Phosphorylation
S18 Phosphorylation
S19 Phosphorylation
Y20 Phosphorylation
S21 Phosphorylation
S22 Phosphorylation
S24 Phosphorylation
Y28 Phosphorylation
Y30 Phosphorylation
K33 Ubiquitination
K38 Methylation
K38 Ubiquitination
S39 Phosphorylation
Y41 Phosphorylation
S55 Phosphorylation
K59 Ubiquitination
K60 Ubiquitination
Y134 Phosphorylation
K140 Ubiquitination
Y217 Phosphorylation
Y220 Phosphorylation
T221 Phosphorylation
S320 Phosphorylation
S328 Phosphorylation
S469 Phosphorylation

Research Backgrounds

Function:

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.

PTMs:

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.
Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).

Family&Domains:

Belongs to the amino acid/polyamine transporter 2 family.

Research Fields

· Organismal Systems > Nervous system > Glutamatergic synapse.

· Organismal Systems > Nervous system > GABAergic synapse.

· Organismal Systems > Digestive system > Protein digestion and absorption.

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