RHOD Antibody - #DF4439
| Product: | RHOD Antibody |
| Catalog: | DF4439 |
| Description: | Rabbit polyclonal antibody to RHOD |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog |
| Mol.Wt.: | 25 KD; 23kD(Calculated). |
| Uniprot: | O00212 |
| RRID: | AB_2836794 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4439, RRID:AB_2836794.
Fold/Unfold
ARHD; Ras homolog D; Ras homolog gene family member A; Ras homolog gene family member D; Rho; RHO D; Rho related GTP binding protein RhoD; Rho related protein HP1; Rho-related GTP-binding protein RhoD; Rho-related protein HP1; RHOD; RHOD_HUMAN; RhoHP1; RHOM;
Immunogens
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
- O00212 RHOD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLCKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O00212 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S17 | Phosphorylation | Uniprot | |
| K19 | Ubiquitination | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| S138 | Phosphorylation | Uniprot |
Research Backgrounds
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
Cell membrane>Lipid-anchor>Cytoplasmic side. Early endosome.
Note: Colocalizes with RAB5 to early endosomes (By similarity).
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.
Belongs to the small GTPase superfamily. Rho family.
Research Fields
· Organismal Systems > Development > Axon guidance. (View pathway)
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