MLANA Antibody - #AF0204
| Product: | MLANA Antibody |
| Catalog: | AF0204 |
| Description: | Rabbit polyclonal antibody to MLANA |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 15kDa; 13kD(Calculated). |
| Uniprot: | Q16655 |
| RRID: | AB_2833288 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0204, RRID:AB_2833288.
Fold/Unfold
Antigen LB39 AA; Antigen LB39-AA; Antigen SK29 AA; Antigen SK29-AA; MAR1_HUMAN; MART 1; MART-1; MART1; Melan A; Melan A protein; Melanoma antigen recognized by T cells 1; Melanoma antigen recognized by T-cells 1; MLAN A; MLANA; OTTHUMP00000021036; OTTHUMP00000021037; OTTHUMP00000021038; Protein Melan-A;
Immunogens
- Q16655 MAR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPREDAHFIYGYPKKGHGHSYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLHVGTQCALTRRCPQEGFDHRDSKVSLQEKNCEPVVPNAPPAYEKLSAEQSPPPYSP
PTMs - Q16655 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S87 | Phosphorylation | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| Y116 | Phosphorylation | Uniprot |
Research Backgrounds
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Acylated.
Endoplasmic reticulum membrane>Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus>trans-Golgi network membrane. Melanosome.
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Expression is restricted to melanoma and melanocyte cell lines and retina.
Interacts with PMEL. Interacts with GPR143.
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